ArticlePloS one2014
L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
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- Histidine is essential for growth of Komagataella phaffii cultured in YPA medium.FEBS open bio · 2022Article
- Characterization of Cold-TolerantMicroorganisms · 2021Article
- Rutin, A Natural Inhibitor of IGPD Protein, Partially Inhibits Biofilm Formation inFrontiers in pharmacology · 2021Article
- Yeast biofilm in food realms: occurrence and control.World journal of microbiology & biotechnology · 2020Review
- Bacterial Biodiversity of Extra Virgin Olive Oils and Their Potential Biotechnological Exploitation.Microorganisms · 2020Article
- Consolidated bioprocessing of corn cob-derived hemicellulose: engineered industrialBiotechnology for biofuels · 2020Article
- Process optimization ofRSC advances · 2019Article
- In vitro activity and In vivo efficacy of Isoliquiritigenin against Staphylococcus xylosus ATCC 700404 by IGPD target.PloS one · 2019Article
- Azithromycin Inhibits Biofilm Formation byFrontiers in pharmacology · 2018Article
- Histidine Metabolism and IGPD Play a Key Role in Cefquinome Inhibiting Biofilm Formation ofFrontiers in microbiology · 2018Article
- Comparative Proteomic Analysis Provides insight into the Key Proteins as Possible Targets Involved in Aspirin Inhibiting Biofilm Formation ofFrontiers in pharmacology · 2017Article
- Flor Yeast: New Perspectives Beyond Wine Aging.Frontiers in microbiology · 2016Review
- Correction: L-Histidine Inhibits Biofilm Formation and FLO11-Associated Phenotypes in Saccharomyces cerevisiae Flor Yeasts.PloS one · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flor yeasts of Saccharomyces cerevisiae have an innate diversity of Flo11p which codes for a highly hydrophobic and anionic cell-wall glycoprotein with a fundamental role in biofilm formation. In this study, 380 nitrogen compounds were administered to three S. cerevisiae flor strains handling Flo11p alleles with different expression levels. S. cerevisiae strain S288c was used as the reference strain as it cannot produce Flo11p. The flor strains generally metabolized amino acids and dipeptides as the sole nitrogen source, although with some exceptions regarding L-histidine and histidine containing dipeptides. L-histidine completely inhibited growth and its effect on viability was inversely related to Flo11p expression. Accordingly, L-histidine did not affect the viability of the Δflo11 and S288c strains. Also, L-histidine dramatically decreased air-liquid biofilm formation and adhesion to polystyrene of the flor yeasts with no effect on the transcription level of the Flo11p gene. Moreover, L-histidine modified the chitin and glycans content on the cell-wall of flor yeasts. These findings reveal a novel biological activity of L-histidine in controlling the multicellular behavior of yeasts [corrected].
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