ArticlePloS one2014
Characterization of the CD14++CD16+ monocyte population in human bone marrow.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Overview of methods that determine mitochondrial function in human disease.Metabolism: clinical and experimental · 2025Review
- Monocytes across life span in HIV infection: lights and shadows.Current opinion in HIV and AIDS · 2025Review
- Review
- Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34Cardiovascular diabetology · 2024Article
- Osteoclastogenesis of human peripheral blood, bone marrow, and cord blood monocytes.Scientific reports · 2023Article
- Reduced Percentage of CD14International journal of molecular sciences · 2022Article
- Phenotypic and Functional Heterogeneity of Monocyte Subsets in Chronic Heart Failure Patients.Biology · 2022Review
- Acetaldehyde exposure underlies functional defects in monocytes induced by excessive alcohol consumption.Scientific reports · 2021Article
- Monocyte Subset Recruitment Marker Profile Is Inversely Associated With Blood ApoA1 Levels.Frontiers in immunology · 2021Article
- Participation of Monocyte Subpopulations in Progression of Experimental Endotoxemia (EE) and Systemic Inflammation.Journal of immunology research · 2021Review
- Fractalkine/CX3CL1 in Neoplastic Processes.International journal of molecular sciences · 2020Review
- Patterns, Profiles, and Parsimony: Dissecting Transcriptional Signatures From Minimal Single-Cell RNA-Seq Output With SALSA.Frontiers in genetics · 2020Article
- The HIV Reservoir in Monocytes and Macrophages.Frontiers in immunology · 2019Review
- Hemodialysis-related changes in phenotypical features of monocytes.Scientific reports · 2018Article
- The multifaceted link between inflammation and human diseases.Journal of cellular physiology · 2018Review
- Peripheral blood monocytes show increased osteoclast differentiation potential compared to bone marrow monocytes.Heliyon · 2018Article
- Gap junctional communication is involved in differentiation of osteoclasts from bone marrow and peripheral blood monocytes.Heliyon · 2018Article
- Crosstalk between substance P and calcitonin gene-related peptide during heterotopic ossification in murine Achilles tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction.Microbiome · 2018Article
- Monocyte alterations in rheumatoid arthritis are dominated by preterm release from bone marrow and prominent triggering in the joint.Annals of the rheumatic diseases · 2018Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous studies have divided blood monocytes according to their expression of the surface markers CD14 and CD16 into following subsets: classical CD14(++)CD16(-), intermediate CD14(++)CD16(+) and nonclassical CD14(+)CD16(++) monocytes. These subsets differ in phenotype and function and are further correlated to cardiovascular disease, inflammation and cancer. However, the CD14/CD16 nature of resident monocytes in human bone marrow remains largely unknown. In the present study, we identified a major population of CD14(++)CD16(+) monocytes by using cryopreserved bone marrow mononuclear cells from healthy donors. These cells express essential monocyte-related antigens and chemokine receptors such as CD11a, CD18, CD44, HLA-DR, Ccr2, Ccr5, Cx3cr1, Cxcr2 and Cxcr4. Notably, the expression of Ccr2 was inducible during culture. Furthermore, sorted CD14(++)CD16(+) bone marrow cells show typical macrophage morphology, phagocytic activity, angiogenic features and generation of intracellular oxygen species. Side-by-side comparison of the chemokine receptor profile with unpaired blood samples also demonstrated that these rather premature medullar monocytes mainly match the phenotype of intermediate and partially of (non)classical monocytes. Together, human monocytes obviously acquire their definitive CD14/CD16 signature in the bloodstream and the medullar monocytes probably transform into CD14(++)CD16- and CD14(+)CD16(++) subsets which appear enriched in the periphery.
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