Evidence map›Paper›PMID 25369144›Full record

ArticleTranslational psychiatry2014

Quantitative proteomics of delirium cerebrospinal fluid.

A Poljak, M Hill, R J Hall, A M MacLullich, M J Raftery, J Tai, S Yan, G A Caplan

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Evaluating Cellular Viability by iTRAQ Proteomic Profiling.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  11. Review
  12. Review
  13. Article
  14. Observational
  15. Can Serum Nitrosoproteome Predict Longevity of Aged Women?International journal of molecular sciences · 2020
    Article
  16. Article
  17. Development of a Dynamic Multi-Protein Signature of Postoperative Delirium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

A Poljak1] Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, NSW, Australia [2] School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia [3] Center for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, Australia.
M HillSchool of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
R J HallEdinburgh Delirium Research Group, University of Edinburgh, Edinburgh, Scotland, UK.
A M MacLullichEdinburgh Delirium Research Group, University of Edinburgh, Edinburgh, Scotland, UK.
M J RafteryBioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, NSW, Australia.
J TaiSchool of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
S YanSchool of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
G A Caplan1] Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia [2] Department of Geriatric Medicine, Prince of Wales Hospital, Sydney, NSW, Australia.
UNSW Sydney · AUUniversity of Edinburgh · GB

Funding

Medical Research Council G108/646
6 · The paper itself

Abstract

Delirium is a common cause and complication of hospitalization in older people, being associated with higher risk of future dementia and progression of existing dementia. However relatively little data are available on which biochemical pathways are dysregulated in the brain during delirium episodes, whether there are protein expression changes common among delirium subjects and whether there are any changes which correlate with the severity of delirium. We now present the first proteomic analysis of delirium cerebrospinal fluid (CSF), and one of few studies exploring protein expression changes in delirium. More than 270 proteins were identified in two delirium cohorts, 16 of which were dysregulated in at least 8 of 17 delirium subjects compared with a mild Alzheimer's disease neurological control group, and 31 proteins were significantly correlated with cognitive scores (mini-mental state exam and acute physiology and chronic health evaluation III). Bioinformatics analyses revealed expression changes in several protein family groups, including apolipoproteins, secretogranins/chromogranins, clotting/fibrinolysis factors, serine protease inhibitors and acute-phase response elements. These data not only provide confirmatory evidence that the inflammatory response is a component of delirium, but also reveal dysregulation of protein expression in a number of novel and unexpected clusters of proteins, in particular the granins. Another surprising outcome of this work is the level of similarity of CSF protein profiles in delirium patients, given the diversity of causes of this syndrome. These data provide additional elements for consideration in the pathophysiology of delirium as well as potential biomarker candidates for delirium diagnosis.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseBiomarkersCerebrospinal Fluid ProteinsDeliriumFemaleHumansMaleProteomicsBiomarkersCerebrospinal Fluid Proteins

Identifiers

PMID25369144
PMCPMC4259987
OpenAlexW2132623165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.