SynthesisPloS one2014
Age-related cataract, cataract surgery and subsequent mortality: a systematic review and meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Association between obesity and age-related cataract: an updated systematic review and dose-response meta-analysis of prospective cohort studies.Frontiers in nutrition · 2023Pooled it
- Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies.Eye (London, England) · 2022Pooled it
- The national and subnational prevalence of cataract and cataract blindness in China: a systematic review and meta-analysis.Journal of global health · 2018Pooled it
- Influence of uncomplicated phacoemulsification on central macular thickness in diabetic patients: a meta-analysis.PloS one · 2015Pooled it
- The role of blue light-filtering and premium intraocular lenses on postoperative falls: A nationwide target trial emulation in Taiwan.Biomedical journal · 2026Article
- Long-term outcomes after phacoemulsification and trabeculectomy in uncontrolled glaucoma and cataract in staged versus combined approaches: a single-center observational study.BMC ophthalmology · 2026Observational
- Mortality following glaucoma surgery in octogenarians with primary open angle glaucoma.International ophthalmology · 2025Article
- Ocular Biometry Profile and Its Associations with Systemic and Demographic Factors in Thai Cataract Patients.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Costs and cost-effectiveness of the Kerala pilot screening programme for diabetic retinopathy in the public health system.Eye (London, England) · 2024Article
- Importance of Grading Cataracts in Predicting Recovery Time and Final Visual Outcomes After Cataract Surgery.Cureus · 2024Article
- Fuch's Endothelial Corneal Dystrophy in Cataract Patients Is Associated with Elevated Levels of Inflammatory Chemokines, but Not Growth Factors, in the Aqueous Humor.International journal of molecular sciences · 2024Article
- Evaluation of the frequency of ABO and Rh-Hr blood-group systems in different acquired cataracts type.BMC research notes · 2023Article
- Potential of GJA8 gene variants in predicting age-related cataract: A comparison of supervised machine learning methods.PloS one · 2023Article
- The Aqueous Stem Bark Extract ofScientifica · 2023Article
- Temporal trajectories of important diseases in the life course and premature mortality in the UK Biobank.BMC medicine · 2022Article
- Evidence on cataract in low- and middle-income countries: an updated review of reviews using the evidence gap maps approach.International health · 2022Review
- Associations of Humidity and Temperature With Cataracts Among Older Adults in China.Frontiers in public health · 2022Article
- Morphological comparison between three-dimensional structure of immortalized human lens epithelial cells and Soemmering's ring.Medical molecular morphology · 2021Article
- Evaluating sedative effects of dexmedetomidine and morphine in the patients with opioid use disorder undergoing cataract surgery.American journal of clinical and experimental immunology · 2021Article
- The potential health benefits of dietary natural plant products in age related eye diseases.Heliyon · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeChanges in lens may reflect the status of systemic health of human beings but the supporting evidences are not well summarized yet. We aimed to determine the relationship of age-related cataract, cataract surgery and long-term mortality by pooling the results of published population-based studies.
methodsWe searched PubMed and Embase from their inception till March, 2014 for population-based studies reporting the associations of any subtypes of age-related cataract, cataract surgery with all-cause mortality. We pooled the effect estimates (hazards ratios [HRs]) under a random effects model.
resultsTotally, we identified 10 unique population-based studies including 39,659 individuals at baseline reporting the associations of any subtypes of cataract with all-cause mortality from 6 countries. The presence of any cataract including cataract surgery was significantly associated with a higher risk of death (pooled HR: 1.43, 95% CI, 1.21, 2.02; P<0.001; I(2) = 64.2%). In the meta-analysis of 9 study findings, adults with nuclear cataract were at higher risks of mortality (pooled HR: 1.55, 95% CI, 1.17, 2.05; P = 0.002; I(2) = 89.2%). In the meta-analysis of 8 study findings, cortical cataract was associated with higher risks of mortality (pooled HR: 1.26, 95% CI, 1.12, 1.42; P<0.001, I(2) = 29.7%). In the meta-analysis of 6 study findings, PSC cataract was associated with higher risks of mortality (pooled HR: 1.37, 95% CI, 1.04, 1.80; P = 0.03; I(2) = 67.3%). The association between cataract surgery and mortality was marginally non-significant by pooling 8 study findings (pooled HR: 1.27, 95% CI, 0.97, 1.66; P = 0.08; I(2)= 76.6%).
conclusionsAll subtypes of age-related cataract were associated with an increased mortality with nuclear cataract having the strongest association among the 3 cataract subtypes. However, cataract surgery was not significantly related to mortality. These findings indicated that changes in lens may serve as markers for ageing and systemic health in general population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.