ArticleJundishapur journal of microbiology2014
Biofilm Formation and Susceptibility to Amphotericin B and Fluconazole in Candida albicans.
Article in Jundishapur journal of microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
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- In Silico Guided Nanoformulation Strategy for Circumvention ofACS omega · 2023Article
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- Inhibition ofPharmaceutics · 2022Article
- The genotypes and virulence attributes of C. albicans isolates from oral leukoplakia.Medicina oral, patologia oral y cirugia bucal · 2021Article
- Eradication ofJournal of fungi (Basel, Switzerland) · 2021Article
- In Vitro Activity of Carbosilane Cationic Dendritic Molecules on Prevention and Treatment ofPharmaceutics · 2020Article
- Genotype Analysis of ClinicalInfection and drug resistance · 2019Article
- Candiduria; a review article with specific data from Iran.Turkish journal of urology · 2018Review
- The efficacy of gaseous ozone against different forms ofCurrent medical mycology · 2017Article
- Resistance ofJundishapur journal of microbiology · 2016Review
- Antifungal Susceptibility Patterns of Candida Species Recovered from Endotracheal Tube in an Intensive Care Unit.Advances in medicine · 2016Article
- In Vitro Susceptibilities of Candida albicans Isolates to Antifungal Agents in Tokat, Turkey.Jundishapur journal of microbiology · 2015Article
- Urinary tract infections and Candida albicans.Central European journal of urology · 2015Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ability of Candida albicans to form biofilms and adhere to host tissues and biomaterial surfaces is an important factor in its pathogenesis. One of the main characteristics of biofilms is their resistance to broad-spectrum anti-microbial drugs.
objectivesIn the present study the formation of biofilm by C. albicans from different sources was evaluated. In addition, the minimum biofilm inhibitory concentration (MBIC) for two antifungals was evaluated. MATERIALS AND
methodsIn total, 120 isolates of C. albicans from different sources (patients with vaginitis, patients with candiduria, bucal cavity and environmental surfaces) were collected. Biofilm formation was determined by the 96-well micro-titeration plate method. MBIC testing was also performed, using the calorimetric indicator resazurin for amphotericin B and fluconazole.
resultsThe results indicated that 100% of C. albicans isolates from different sources had the ability to form biofilms in vitro. Amongst these isolates, 83.3% of isolates had the maximum potential (4+) to form biofilms, while only one (0.9%) of isolates had the minimum ability (1+) to form biofilms. Our results showed that 65.0% of the tested isolates are sensitive to amphotericin B at amounts lower than 10 µg/mL, while only 26.7% are sensitive to fluconazole (had MBIC < 10 µg/mL).
conclusionsAlthough biofilm formation was detected in all tested isolates, there were differences in the ability to form biofilms between isolates from different sources. In addition, there were differences in the MBIC against the two examined antifungals, amphotericin B and fluconazole.
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