ArticleFrontiers in plant science2014
Sustained mitogen-activated protein kinase activation reprograms defense metabolism and phosphoprotein profile in Arabidopsis thaliana.
Article in Frontiers in plant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
- The OXIDATIVE SIGNAL-INDUCIBLE1 kinase regulates plant immunity by linking microbial pattern-induced reactive oxygen species burst to MAP kinase activation.The Plant cell · 2024Article
- The Mitochondrial Blueprint: Unlocking Secondary Metabolite Production.Metabolites · 2024Review
- Phytosulfokine downregulates defense-related WRKY transcription factors and attenuates pathogen-associated molecular pattern-triggered immunity.The Plant journal : for cell and molecular biology · 2024Article
- MAPK Cascades in Plant Microbiota Structure and Functioning.Journal of microbiology (Seoul, Korea) · 2024Review
- Dual control of MAPK activities by AP2C1 and MKP1 MAPK phosphatases regulates defence responses in Arabidopsis.Journal of experimental botany · 2022Article
- Lipid flippases as key players in plant adaptation to their environment.Nature plants · 2021Review
- Exocyst subunit Exo70B2 is linked to immune signaling and autophagy.The Plant cell · 2021Article
- TALEN-BasedFrontiers in plant science · 2021Article
- Sustained Incompatibility between MAPK Signaling and Pathogen Effectors.International journal of molecular sciences · 2020Review
- Phosphorylation of the CAMTA3 Transcription Factor Triggers Its Destabilization and Nuclear Export.Plant physiology · 2020Article
- Proteomic characterization of MPK4 signaling network and putative substrates.Plant molecular biology · 2019Article
- Receptor-Like Cytoplasmic Kinases Directly Link Diverse Pattern Recognition Receptors to the Activation of Mitogen-Activated Protein Kinase Cascades in Arabidopsis.The Plant cell · 2018Article
- MAP kinases associate with high molecular weight multiprotein complexes.Journal of experimental botany · 2018Article
- Quantitative Phosphoproteomic Analysis Reveals Shared and Specific Targets ofMolecular & cellular proteomics : MCP · 2018Article
- Phosphorylation of Arabidopsis MAP Kinase Phosphatase 1 (MKP1) Is Required for PAMP Responses and Resistance against Bacteria.Plant physiology · 2017Article
- A novel family of proline/serine-rich proteins, which are phospho-targets of stress-related mitogen-activated protein kinases, differentially regulates growth and pathogen defense in Arabidopsis thaliana.Plant molecular biology · 2017Article
- Constitutively Active Arabidopsis MAP Kinase 3 Triggers Defense Responses Involving Salicylic Acid and SUMM2 Resistance Protein.Plant physiology · 2017Article
- Mild osmotic stress promotes 4-methoxy indolyl-3-methyl glucosinolate biosynthesis mediated by the MKK9-MPK3/MPK6 cascade in Arabidopsis.Plant cell reports · 2017Article
- Changes in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response.The Plant cell · 2017Article
- Protein phosphatase AP2C1 negatively regulates basal resistance and defense responses to Pseudomonas syringae.Journal of experimental botany · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitogen-activated protein kinases (MAPKs) target a variety of protein substrates to regulate cellular signaling processes in eukaryotes. In plants, the number of identified MAPK substrates that control plant defense responses is still limited. Here, we generated transgenic Arabidopsis thaliana plants with an inducible system to simulate in vivo activation of two stress-activated MAPKs, MPK3, and MPK6. Metabolome analysis revealed that this artificial MPK3/6 activation (without any exposure to pathogens or other stresses) is sufficient to drive the production of major defense-related metabolites, including various camalexin, indole glucosinolate and agmatine derivatives. An accompanying (phospho)proteome analysis led to detection of hundreds of potential phosphoproteins downstream of MPK3/6 activation. Besides known MAPK substrates, many candidates on this list possess typical MAPK-targeted phosphosites and in many cases, the corresponding phosphopeptides were detected by mass spectrometry. Notably, several of these putative phosphoproteins have been reported to be associated with the biosynthesis of antimicrobial defense substances (e.g., WRKY transcription factors and proteins encoded by the genes from the "PEN" pathway required for penetration resistance to filamentous pathogens). Thus, this work provides an inventory of candidate phosphoproteins, including putative direct MAPK substrates, for future analysis of MAPK-mediated defense control. (Proteomics data are available with the identifier PXD001252 via ProteomeXchange, http://proteomecentral.proteomexchange.org).
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