Evidence map›Paper›PMID 25368555›Full record

ReviewFrontiers in neural circuits2014

Dissecting inhibitory brain circuits with genetically-targeted technologies.

Dona K Murphey, Alexander M Herman, Benjamin R Arenkiel

Abstract readReview
In one paragraph

Review in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Task Learning Promotes Plasticity of Interneuron Connectivity Maps in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  8. Article
  9. Neural circuits revealed.Frontiers in neural circuits · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dona K MurpheyDepartment of Neurology, Baylor College of Medicine Houston, TX, USA.
Alexander M HermanProgram in Developmental Biology, Baylor College of Medicine Houston, TX, USA.
Benjamin R ArenkielProgram in Developmental Biology, Baylor College of Medicine Houston, TX, USA ; Department of Molecular and Human Genetics, Baylor College of Medicine Houston, TX, USA ; Department of Neuroscience, Baylor College of Medicine Houston, TX, USA ; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital Houston, TX, USA.

Funding

Mutidisciplinary Training;Brain Disorders &DevelopmentT32NS043124 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SWANN, JOHN WILLIAM · 2002 to 2021
$4.6M
MAPPING CONNECTIVITY ONTO POSTNATAL-BORN NEURONSR01NS078294 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ARENKIEL, BENJAMIN R · 2012 to 2023
$3.6M
NINDS NIH HHS NS078294NINDS NIH HHS R01 NS078294NINDS NIH HHS T32 NS043124NINDS NIH HHS T32NS043124
6 · The paper itself

Abstract

The evolution of genetically targeted tools has begun to allow us to dissect anatomically and functionally heterogeneous interneurons, and to probe circuit function from synapses to behavior. Over the last decade, these tools have been used widely to visualize neurons in a cell type-specific manner, and engage them to activate and inactivate with exquisite precision. In this process, we have expanded our understanding of interneuron diversity, their functional connectivity, and how selective inhibitory circuits contribute to behavior. Here we discuss the relative assets of genetically encoded fluorescent proteins (FPs), viral tracing methods, optogenetics, chemical genetics, and biosensors in the study of inhibitory interneurons and their respective circuits.

Indexed as

AnimalsBrainFluorescent Antibody TechniqueInterneuronsLuminescent ProteinsNerve NetNeural InhibitionOptogeneticsTransduction, GeneticLuminescent Proteinschannelrhodopsinchemical geneticsinterneuron diversityinterneuronsoptogeneticsviral tracing

Identifiers

PMID25368555
PMCPMC4201106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.