ArticleJournal of Korean medical science2014
Gender differences in the association between serum γ-glutamyltransferase and blood pressure change: a prospective community-based cohort study.
Article in Journal of Korean medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- From Serum to Genome: γ-Glutamyltransferase Gene Family Variants Shape Ischemic Stroke Risk via Sex-Specific Gene-Environment Interactions.Life (Basel, Switzerland) · 2026Article
- Association between parental high-sensitive C-reactive protein and hypertension in offspring: an intergenerational study.Clinical hypertension · 2025Article
- Can Serum Gamma-Glutamyl Transferase Predict All-Cause Mortality in Hypertensive Patients?Cureus · 2024Article
- Gamma-glutamyl transferase and risk of all-cause and disease-specific mortality: a nationwide cohort study.Scientific reports · 2023Article
- Evaluation of Epigenetic Age Acceleration Scores and Their Associations with CVD-Related Phenotypes in a Population Cohort.Biology · 2022Article
- Evaluation of Relationship between Serum Liver Enzymes and Hypertension: A Cross-Sectional Study Based on Data from Rafsanjan Cohort Study.International journal of hypertension · 2022Article
- Sexual dimorphism in glutathione metabolism and glutathione-dependent responses.Redox biology · 2020Review
- Association between serum liver enzymes and hypertension: a cross-sectional study in Bangladeshi adults.BMC cardiovascular disorders · 2020Article
- Sex-Gender Variable: Methodological Recommendations for Increasing Scientific Value of Clinical Studies.Cells · 2019Review
- Serum gamma-glutamyl transferase is a predictor of mortality in patients with acute myocardial infarction.Medicine · 2018Observational
- Association of serum bilirubin level with lung function decline: a Korean community-based cohort study.Respiratory research · 2018Article
- The Association between Parameters of Socioeconomic Status and Hypertension in Korea: the Korean Genome and Epidemiology Study.Journal of Korean medical science · 2016Article
- Observational
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5 authors.
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Abstract
We evaluated the gender differences in the relation of baseline serum γ-glutamyltransferase (GGT) levels to blood pressure (BP) change during 4 yr. 4,025 normotensive subjects (1,945 men and 2,080 women) who aged 40-69 yr at baseline participated in the Ansung-Ansan cohort of the Korean Genome Epidemiology Study were included. The associations of GGT with baseline BP or 4-yr change of BP were evaluated. GGT levels were associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) at baseline after adjusting for age, body mass index (BMI), HDL-cholesterol, triglyceride, C-reactive protein (CRP), current smoking status and alcohol intake (SBP, β=1.28, P<0.001; DBP, β=1.41, P<0.001). GGT levels were also associated with 4-yr change in BP after adjusting for age, BMI, HDL-cholesterol, triglyceride, CRP, current smoking status, alcohol intake and SBP (SBP, β=1.08, P=0.001; DBP, β=0.64, P=0.003). This association was statistically significant in men (SBP, β=1.82, P<0.001; DBP, β=1.05, P=0.001), but not in women (SBP, β=0.38, P=0.466; DBP, β=-0.37, P=0.304). Remarkably, this association between GGT and BP was significant in men at 40-49 yr of age. In summary, we found positive associations between GGT levels at baseline and the change of BP. The relation of GGT level and the change of BP was only significant in men, not in women, which warrants further studies to elucidate the biologic mechanisms.
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