ArticleSchizophrenia bulletin2015
Fronto-striatal dysfunction during reward processing in unaffected siblings of schizophrenia patients.
Article in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- A Meta-Analysis of Neural Correlates of Reward Anticipation in Individuals at Clinical Risk for Schizophrenia.The international journal of neuropsychopharmacology · 2023Pooled it
- Trial
- Distinct neural responses to punishment anticipation in violent and non-violent individuals with schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Reward-Related Brain Function as an Endophenotype in the Mood-Psychosis Spectrum.Biological psychiatry global open science · 2026Article
- Schizophrenia endophenotypes: a review of neurophysiological, neuropsychological, and social cognition markers.Frontiers in psychiatry · 2026Review
- Psychedelics and schizophrenia: a double-edged sword.Molecular psychiatry · 2025Review
- Investigating changes in the premotor cortex-derived frontal-striatal-thalamic subcircuit in attenuated psychosis syndrome.Brain imaging and behavior · 2024Article
- Compressed cerebro-cerebellar functional gradients in children and adolescents with attention-deficit/hyperactivity disorder.Human brain mapping · 2024Article
- Striatal Response to Reward Anticipation as a Biomarker for Schizophrenia and Negative Symptoms: Effects, Test-Retest Reliability, and Stability Across Sites.Schizophrenia bulletin · 2024Article
- Neuroimaging of social motivation during winning and losing: Associations with social anhedonia across the psychosis spectrum.Neuropsychologia · 2023Article
- Insular and Striatal Correlates of Uncertain Risky Reward Pursuit in Schizophrenia.Schizophrenia bulletin · 2023Article
- Activation of Internal Correctness Monitoring Circuitry in Youths With Psychosis Spectrum Symptoms.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Reward Processing as an Indicator of Vulnerability or Compensatory Resilience in Psychoses? Results From a Twin Study.Biological psychiatry global open science · 2023Article
- Subjective reward processing and catechol-Frontiers in psychiatry · 2022Article
- Altered Spontaneous Brain Activity Patterns of Meibomian Gland Dysfunction in Severely Obese Population Measured Using the Fractional Amplitude of Low-Frequency Fluctuations.Frontiers in psychiatry · 2022Article
- The psychosis human connectome project: An overview.NeuroImage · 2021Article
- Relationship of ventral striatum activation during effort discounting to clinical amotivation severity in schizophrenia.NPJ schizophrenia · 2021Article
- Early-Stage Repetitive Transcranial Magnetic Stimulation Altered Posterior-Anterior Cerebrum Effective Connectivity in Methylazoxymethanol Acetate Rats.Frontiers in neuroscience · 2021Article
- Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives.Journal of psychiatry & neuroscience : JPN · 2020Article
- Resting-state functional connectivity of neural circuits associated with primary and secondary rewards in patients with bipolar disorder.Social cognitive and affective neuroscience · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a psychiatric disorder that is associated with impaired functioning of the fronto-striatal network, in particular during reward processing. However, it is unclear whether this dysfunction is related to the illness itself or whether it reflects a genetic vulnerability to develop schizophrenia. Here, we examined reward processing in unaffected siblings of schizophrenia patients using functional magnetic resonance imaging. Brain activity was measured during reward anticipation and reward outcome in 27 unaffected siblings of schizophrenia patients and 29 healthy volunteers using a modified monetary incentive delay task. Task performance was manipulated online so that all subjects won the same amount of money. Despite equal performance, siblings showed reduced activation in the ventral striatum, insula, and supplementary motor area (SMA) during reward anticipation compared to controls. Decreased ventral striatal activation in siblings was correlated with sub-clinical negative symptoms. During the outcome of reward, siblings showed increased activation in the ventral striatum and orbitofrontal cortex compared to controls. Our finding of decreased activity in the ventral striatum during reward anticipation and increased activity in this region during receiving reward may indicate impaired cue processing in siblings. This is consistent with the notion of dopamine dysfunction typically associated with schizophrenia. Since unaffected siblings share on average 50% of their genes with their ill relatives, these deficits may be related to the genetic vulnerability for schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.