Evidence map›Paper›PMID 25368359›Full record

SynthesisThe British journal of psychiatry : the journal of mental science2014

Height in relation to dementia death: individual participant meta-analysis of 18 UK prospective cohort studies.

Tom C Russ, Mika Kivimäki, John M Starr, Emmanuel Stamatakis, G David Batty

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The British journal of psychiatry : the journal of mental science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tom C RussTom C. Russ, PhD, MRCPsych, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Scottish Dementia Clinical Research Network, National Health Service (NHS) Scotland, Centre for Cognitive Ageing and Cognitive Epidemiology, and Division of Psychiatry, University of Edinburgh; Mika Kivimäki, PhD, Department of Epidemiology and Public Health, University College London; John M. Starr, PhD, FRCPEd, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Scottish Dementia Clinical Research Network, NHS Scotland, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Emmanuel Stamatakis, PhD, Charles Perkins Centre, and Exercise and Sport Sciences, Faculty of Health Sciences, University of Sydney, Australia; G. David Batty, PhD, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, and Department of Epidemiology and Public Health, University College London, UK.
Mika KivimäkiTom C. Russ, PhD, MRCPsych, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Scottish Dementia Clinical Research Network, National Health Service (NHS) Scotland, Centre for Cognitive Ageing and Cognitive Epidemiology, and Division of Psychiatry, University of Edinburgh; Mika Kivimäki, PhD, Department of Epidemiology and Public Health, University College London; John M. Starr, PhD, FRCPEd, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Scottish Dementia Clinical Research Network, NHS Scotland, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Emmanuel Stamatakis, PhD, Charles Perkins Centre, and Exercise and Sport Sciences, Faculty of Health Sciences, University of Sydney, Australia; G. David Batty, PhD, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, and Department of Epidemiology and Public Health, University College London, UK.
John M StarrTom C. Russ, PhD, MRCPsych, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Scottish Dementia Clinical Research Network, National Health Service (NHS) Scotland, Centre for Cognitive Ageing and Cognitive Epidemiology, and Division of Psychiatry, University of Edinburgh; Mika Kivimäki, PhD, Department of Epidemiology and Public Health, University College London; John M. Starr, PhD, FRCPEd, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Scottish Dementia Clinical Research Network, NHS Scotland, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Emmanuel Stamatakis, PhD, Charles Perkins Centre, and Exercise and Sport Sciences, Faculty of Health Sciences, University of Sydney, Australia; G. David Batty, PhD, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, and Department of Epidemiology and Public Health, University College London, UK.
Emmanuel StamatakisTom C. Russ, PhD, MRCPsych, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Scottish Dementia Clinical Research Network, National Health Service (NHS) Scotland, Centre for Cognitive Ageing and Cognitive Epidemiology, and Division of Psychiatry, University of Edinburgh; Mika Kivimäki, PhD, Department of Epidemiology and Public Health, University College London; John M. Starr, PhD, FRCPEd, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Scottish Dementia Clinical Research Network, NHS Scotland, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Emmanuel Stamatakis, PhD, Charles Perkins Centre, and Exercise and Sport Sciences, Faculty of Health Sciences, University of Sydney, Australia; G. David Batty, PhD, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, and Department of Epidemiology and Public Health, University College London, UK.
G David BattyTom C. Russ, PhD, MRCPsych, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Scottish Dementia Clinical Research Network, National Health Service (NHS) Scotland, Centre for Cognitive Ageing and Cognitive Epidemiology, and Division of Psychiatry, University of Edinburgh; Mika Kivimäki, PhD, Department of Epidemiology and Public Health, University College London; John M. Starr, PhD, FRCPEd, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Scottish Dementia Clinical Research Network, NHS Scotland, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Emmanuel Stamatakis, PhD, Charles Perkins Centre, and Exercise and Sport Sciences, Faculty of Health Sciences, University of Sydney, Australia; G. David Batty, PhD, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, and Department of Epidemiology and Public Health, University College London, UK.

Funding

Socioeconomic gradient in CHD in early old ageR01HL036310 · NHLBI · UNIVERSITY OF LONDON · PI KIVIMAKI, MIKA J, MARMOT, MICHAEL G · 1986 to 2012
$3.1M
Health behaviors over the adult lifecourse and cognitive agingR01AG034454 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2009 to 2013
$1.5M
Biotechnology and Biological Sciences Research CouncilMedical Research Council K013351Medical Research Council MR/K013351/1Medical Research Council MR/K026992/1NHLBI NIH HHS R01 HL036310NHLBI NIH HHS R01HL036310NIA NIH HHS R01 AG034454NIA NIH HHS R01AG034454
6 · The paper itself

Abstract

backgroundThat risk factors measured in middle age may not fully explain future dementia risk implicates exposures acting earlier in life. Height may capture early-life illness, adversity, nutrition and psychosocial stress.

aimsTo investigate the little-explored association between height and dementia death. Method Individual participant meta-analysis using 18 prospective general population cohort studies with identical methodologies (1994-2008; n = 181 800).

resultsMean follow-up of 9.8 years gave rise to 426 and 667 dementia deaths in men and women respectively. The mean heights were 174.4 cm (s.d. = 7.3) for men and 161.0 cm (s.d. = 6.8) for women. In analyses taking into account multiple covariates, increasing height was related to lower rates of death from dementia in a dose-response pattern (P ⩽ 0.01 for trend). There was evidence of a differential effect by gender (P = 0.016 for interaction). Thus, the association observed in men (hazard ratio per s.d. decrease in height 1.24, 95% CI 1.11-1.39) was markedly stronger than that apparent in women (HR = 1.13, 95% CI 1.03-1.24).

conclusionsEarly-life circumstances, indexed by adult height, may influence later dementia risk.

Indexed as

Body HeightDementiaHumansRisk FactorsUnited Kingdom

Identifiers

PMID25368359
PMCPMC4217025

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.