ArticleProceedings of the National Academy of Sciences of the United States of America2014
Deciding whether follow-up studies have replicated findings in a preliminary large-scale omics study.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- ProteoForge: An Imputation-Aware Framework for Differential Proteoform Discovery in Bottom-Up Proteomics.Journal of proteome research · 2026Article
- A Statistical Framework for Measuring Reproducibility and Replicability of High-Throughput Experiments From Multiple Sources.Statistics in medicine · 2026Article
- Controlling FDR in selecting group-level simultaneous signals from multiple data sources with application to the National COVID Collaborative Cohort data.Journal of applied statistics · 2026Article
- Variable Selection with FDR Control for Noisy Data - An Application to Screening Metabolites that Are Associated with Breast Cancer and Colorectal Cancer.Journal of data science : JDS · 2025Article
- False discovery rate-controlled multiple testing for union null hypotheses: a knockoff-based approach.Biometrics · 2023Article
- Nucleated red blood cells explain most of the association between DNA methylation and gestational age.Communications biology · 2023Article
- DETECTING MULTIPLE REPLICATING SIGNALS USING ADAPTIVE FILTERING PROCEDURES.Annals of statistics · 2022Article
- Replicability analysis in genome-wide association studies via Cartesian hidden Markov models.BMC bioinformatics · 2019Article
- Reproducibility and replicability of rodent phenotyping in preclinical studies.Neuroscience and biobehavioral reviews · 2018Review
- Training replicable predictors in multiple studies.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Optimal detection of weak positive latent dependence between two sequences of multiple tests.Journal of multivariate analysis · 2017Article
- Extracting replicable associations across multiple studies: Empirical Bayes algorithms for controlling the false discovery rate.PLoS computational biology · 2017Article
- Article
- Identification of unique venous thromboembolism-susceptibility variants in African-Americans.Thrombosis and haemostasis · 2017Article
- A powerful statistical framework for generalization testing in GWAS, with application to the HCHS/SOL.Genetic epidemiology · 2017Article
- The phenotypic legacy of admixture between modern humans and Neandertals.Science (New York, N.Y.) · 2016Article
- Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.American journal of human genetics · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We propose a formal method to declare that findings from a primary study have been replicated in a follow-up study. Our proposal is appropriate for primary studies that involve large-scale searches for rare true positives (i.e., needles in a haystack). Our proposal assigns an r value to each finding; this is the lowest false discovery rate at which the finding can be called replicated. Examples are given and software is available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.