ArticleInfection and immunity2015
New iron acquisition system in Bacteroidetes.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Genetic causal association between gut microbiota and sepsis: Evidence from a two-sample bidirectional Mendelian randomization analysis.Journal of intensive medicine · 2024Article
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- Sodium butyrate supplementation impacts the gastrointestinal bacteria of dairy calves before weaning.Applied microbiology and biotechnology · 2023Article
- Cross-feeding in the gut microbiome: Ecology and mechanisms.Cell host & microbe · 2023Review
- Impact of sucroferric oxyhydroxide on the oral and intestinal microbiome in hemodialysis patients.Scientific reports · 2022Article
- Xenosiderophore Utilization Promotes Bacteroides thetaiotaomicron Resilience during Colitis.Cell host & microbe · 2020Article
- Impacts of the Plateau Environment on the Gut Microbiota and Blood Clinical Indexes in Han and Tibetan Individuals.mSystems · 2020Article
- Gamma-aminobutyric acid-producing lactobacilli positively affect metabolism and depressive-like behaviour in a mouse model of metabolic syndrome.Scientific reports · 2019Article
- Genome sequence and comparative genomic analysis of a clinically important strain CD11-4 ofGut pathogens · 2018Article
- Identifying the Genes Responsible for Iron-Limited Condition inBioMed research international · 2017Article
- Evidence for a LOS and a capsular polysaccharide in Capnocytophaga canimorsus.Scientific reports · 2016Article
- Investigation of TbfA in Riemerella anatipestifer using plasmid-based methods for gene over-expression and knockdown.Scientific reports · 2016Article
- Article
- Iron and zinc exploitation during bacterial pathogenesis.Metallomics : integrated biometal science · 2015Review
- Only a subset of C. canimorsus strains is dangerous for humans.Emerging microbes & infections · 2015Article
- Draft Genome Sequences of Three Capnocytophaga canimorsus Strains Isolated from Septic Patients.Genome announcements · 2015Article
- Draft Genome Sequences of Three Capnocytophaga cynodegmi Strains Isolated from the Oral Cavity of Healthy Dogs.Genome announcements · 2015Article
- Draft Genome Sequences of Three Capnocytophaga canimorsus Strains Isolated from Healthy Canine Oral Cavities.Genome announcements · 2015Article
- Glycan-foraging systems reveal the adaptation of Capnocytophaga canimorsus to the dog mouth.mBio · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capnocytophaga canimorsus, a dog mouth commensal and a member of the Bacteroidetes phylum, causes rare but often fatal septicemia in humans that have been in contact with a dog. Here, we show that C. canimorsus strains isolated from human infections grow readily in heat-inactivated human serum and that this property depends on a typical polysaccharide utilization locus (PUL), namely, PUL3 in strain Cc5. PUL are a hallmark of Bacteroidetes, and they encode various products, including surface protein complexes that capture and process polysaccharides or glycoproteins. The archetype system is the Bacteroides thetaiotaomicron Sus system, devoted to starch utilization. Unexpectedly, PUL3 conferred the capacity to acquire iron from serotransferrin (STF), and this capacity required each of the seven encoded proteins, indicating that a whole Sus-like machinery is acting as an iron capture system (ICS), a new and unexpected function for Sus-like machinery. No siderophore could be detected in the culture supernatant of C. canimorsus, suggesting that the Sus-like machinery captures iron directly from transferrin, but this could not be formally demonstrated. The seven genes of the ICS were found in the genomes of several opportunistic pathogens from the Capnocytophaga and Prevotella genera, in different isolates of the severe poultry pathogen Riemerella anatipestifer, and in strains of Bacteroides fragilis and Odoribacter splanchnicus isolated from human infections. Thus, this study describes a new type of ICS that evolved in Bacteroidetes from a polysaccharide utilization system and most likely represents an important virulence factor in this group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.