Evidence map›Paper›PMID 25368014›Full record

ReviewCold Spring Harbor perspectives in medicine2014

Induced pluripotent stem cells in dermatology: potentials, advances, and limitations.

Ganna Bilousova, Dennis R Roop

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ganna BilousovaDepartment of Dermatology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045 Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045.
Dennis R RoopDepartment of Dermatology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045 Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045.

Funding

Transgenic and Gene Targeting CoreP30AR057212 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI NORRIS, DAVID A. · 2009 to 2018
$6.2M
Testing the Therapeutic Potential of iPS Cells for Inherited Skin DiseasesR01AR059947 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI ROOP, DENNIS · 2012 to 2017
$2.1M
NIAMS NIH HHS P30 AR057212NIAMS NIH HHS R01 AR059947NIAMS NIH HHS R01AR059947
6 · The paper itself

Abstract

The discovery of methods for reprogramming adult somatic cells into induced pluripotent stem cells (iPSCs) has raised the possibility of producing truly personalized treatment options for numerous diseases. Similar to embryonic stem cells (ESCs), iPSCs can give rise to any cell type in the body and are amenable to genetic correction by homologous recombination. These ESC properties of iPSCs allow for the development of permanent corrective therapies for many currently incurable disorders, including inherited skin diseases, without using embryonic tissues or oocytes. Here, we review recent progress and limitations of iPSC research with a focus on clinical applications of iPSCs and using iPSCs to model human diseases for drug discovery in the field of dermatology.

Indexed as

Cell DifferentiationCellular ReprogrammingGenetic TherapyHumansInduced Pluripotent Stem CellsMosaicismSkin DiseasesSkin Diseases, Genetic

Identifiers

PMID25368014
PMCPMC4208713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.