Evidence map›Paper›PMID 25367915›Full record

ArticleAntimicrobial agents and chemotherapy2015

Overproduction of the MtrCDE efflux pump in Neisseria gonorrhoeae produces unexpected changes in cellular transcription patterns.

Elizabeth A Ohneck, Maira Goytia, Corinne E Rouquette-Loughlin, Sandeep J Joseph, Timothy D Read, Ann E Jerse, William M Shafer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Transcriptional regulation of theMicrobiology (Reading, England) · 2022
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. mSystems
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elizabeth A OhneckDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Maira GoytiaDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Corinne E Rouquette-LoughlinDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Sandeep J JosephDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Timothy D ReadDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Ann E JerseDepartment of Microbiology and Immunology, F. Edward Herbert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
William M ShaferDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA Laboratories of Bacterial Pathogenesis, VA Medical Center, Decatur, Georgia, USA wshafer@emory.edu.
Emory University · USAtlanta VA Medical Center · USUniformed Services University of the Health Sciences · US

Funding

Trichomonas Typing SystemU19AI031496 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SPARLING, PHILIP FREDERICK · 1995 to 2014
$24.9M
GONOCOCCI: GENETICS OF RESISTANCE TO PMN PROTEINSR01AI021150 · NIAID · EMORY UNIVERSITY · PI SHAFER, WILLIAM MAURICE · 1985 to 2025
$5.5M
Gonococci: Genetics of Resistance to PMN ProteinsR37AI021150 · NIAID · EMORY UNIVERSITY · PI SHAFER, WILLIAM MAURICE · 2010 to 2019
$3.9M
GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICER01AI042053 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI JERSE, ANN E. · 1999 to 2014
$3.8M
Gonococcal Infection and Gene Expression in Female MiceR56AI042053 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI JERSE, ANN E. · 2009 to 2009
$275k
Gonococcal Mechanisms to Evade Host DefensesI01BX000112 · VA · VETERANS HEALTH ADMINISTRATION · PI SHAFER, WILLIAM MAURICE · 2009 to 2017
–
THE EPIDEMIOLOGY OF STDS IN RURAL NORTH CAROLINAU01AI031496 · NIAID · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI SPARLING, PHILIP FREDERICK · 1991 to 1994
–
BLRD VA I01 BX000112NIAID NIH HHS AI021150-29NIAID NIH HHS AI031496-22NIAID NIH HHS AI096788NIAID NIH HHS AI42053NIAID NIH HHS R01 AI021150NIAID NIH HHS R01 AI042053NIAID NIH HHS R37 AI021150NIAID NIH HHS R56 AI042053NIAID NIH HHS U19 AI031496
6 · The paper itself

Abstract

The global consequence of drug efflux gene overexpression in bacteria has not been specifically analyzed because strains showing high-level expression typically have mutations in genes encoding regulatory proteins that control other genes. Results from a transcriptional profiling study performed with a strain of Neisseria gonorrhoeae that is capable of high-level transcription of the mtrCDE efflux pump operon independently of control by cognate regulatory proteins revealed that its overexpression has ramifications for systems other than drug efflux.

Indexed as

Gene Expression ProfilingGene Expression Regulation, BacterialGenes, MDRNeisseria gonorrhoeaeReal-Time Polymerase Chain ReactionTranscription, Genetic

Identifiers

PMID25367915
PMCPMC4291417
OpenAlexW2116277671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.