ArticleMolecular neurobiology2015
Vitamin C Attenuates Isoflurane-Induced Caspase-3 Activation and Cognitive Impairment.
Article in Molecular neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- The antioxidative effect of STAT3 involved in cellular vulnerability to isoflurane.BMC neuroscience · 2024Article
- Research Advances of Mitochondrial Dysfunction in Perioperative Neurocognitive Disorders.Neurochemical research · 2023Review
- Ascorbate deficiency confers resistance to hippocampal neurodegeneration after asphyxial cardiac arrest in juvenile rats.Pediatric research · 2022Article
- Tetraethylammonium chloride reduces anaesthetic-induced neurotoxicity in Caenorhabditis elegans and mice.British journal of anaesthesia · 2022Article
- Article
- Genome-Wide Screen of the Hippocampus in Aged Rats Identifies Mitochondria, Metabolism and Aging Processes Implicated in Sevoflurane Anesthesia.Frontiers in aging neuroscience · 2020Article
- GLYX-13 pretreatment ameliorates long-term isoflurane exposure-induced cognitive impairment in mice.Neural regeneration research · 2020Article
- Notoginsenoside R1 attenuates sevoflurane-induced neurotoxicity.Translational neuroscience · 2020Article
- DNA Methylation Manipulation of Memory Genes Is Involved in Sevoflurane Induced Cognitive Impairments in Aged Rats.Frontiers in aging neuroscience · 2020Article
- Mesenchymal stromal cells attenuate sevoflurane-induced apoptosis in human neuroglioma H4 cells.BMC anesthesiology · 2018Article
- miRNA-21 Expression in the Serum of Elderly Patients with Acute Myocardial Infarction.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Anesthetic Isoflurane Induces DNA Damage Through Oxidative Stress and p53 Pathway.Molecular neurobiology · 2017Article
- Persistent mitoKMolecular neurobiology · 2017Article
- Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels.American journal of translational research · 2017Article
- Recombinant human brain-derived neurotrophic factor prevents neuronal apoptosis in a novel in vitro model of subarachnoid hemorrhage.Neuropsychiatric disease and treatment · 2017Article
- Lasting impact of general anaesthesia on the brain: mechanisms and relevance.Nature reviews. Neuroscience · 2016Review
- Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice.Scientific reports · 2016Article
- Immune Modulation by Volatile Anesthetics.Anesthesiology · 2016Review
- Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells.Acta pharmacologica Sinica · 2016Article
- Protective Effect of Mangifera indica Linn., Cocos nucifera Linn., and Averrhoa carambola Linn. Extracts against Ultraviolet B-Induced Damage in Human Keratinocytes.Evidence-based complementary and alternative medicine : eCAM · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Anesthetic isoflurane has been reported to induce caspase-3 activation. The underlying mechanism(s) and targeted intervention(s), however, remain largely to be determined. Vitamin C (VitC) inhibits oxidative stress and apoptosis. We therefore employed VitC to further determine the up-stream mechanisms and the down-stream consequences of the isoflurane-induced caspase-3 activation. H4 human neuroglioma cells overexpressed human amyloid precursor protein (H4-APP cells) and rat neuroblastoma cells were treated either with (1) 2% isoflurane or (2) with the control condition, plus saline or 400 μM VitC for 3 or 6 h. Western blot analysis and fluorescence assay were utilized at the end of the experiments to determine caspase-3 activation, levels of reactive oxygen species and ATP, and mitochondrial function. The interaction of isoflurane (1.4% for 2 h) and VitC (100 mg/kg) on cognitive function in mice was also assessed in the fear conditioning system. Here, we show for the first time that the VitC treatment attenuated the isoflurane-induced caspase-3 activation. Moreover, VitC mitigated the isoflurane-induced increases in the levels of reactive oxygen species, opening of mitochondrial permeability transition pore, reduction in mitochondrial membrane potential, and the reduction in ATP levels in the cells. Finally, VitC ameliorated the isoflurane-induced cognitive impairment in the mice. Pending confirmation from future studies, these results suggested that VitC attenuated the isoflurane-induced caspase-3 activation and cognitive impairment by inhibiting the isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels. These findings would promote further research into the underlying mechanisms and targeted interventions of anesthesia neurotoxicity.
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Registered trials
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