ArticlePlant physiology2014
The nitrate transporter MtNPF6.8 (MtNRT1.3) transports abscisic acid and mediates nitrate regulation of primary root growth in Medicago truncatula.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 57 citations in OpenAlex.
- Functional characterization of NRT1/PTR FAMILY transporters: looking for a needle in a haystack.The New phytologist · 2026Review
- Optimizing Nutrient Dynamics for Crop Resilience to Abiotic Stress: An Endogenous Phytohormone Perspective.Plants (Basel, Switzerland) · 2025Review
- Functional and Molecular Characterization of Plant Nitrate Transporters Belonging to NPF (NRT1/PTR) 6 Subfamily.International journal of molecular sciences · 2024Review
- NPF and NRT2 fromPlants (Basel, Switzerland) · 2024Review
- Review
- Genome-Wide Analysis of theInternational journal of molecular sciences · 2023Article
- Article
- An Integrated Regulatory Network of mRNAs, microRNAs, and lncRNAs Involved in Nitrogen Metabolism of Moso Bamboo.Frontiers in genetics · 2022Article
- The Nitrate Transporter MtNPF6.8 Is a Master Sensor of Nitrate Signal in the Primary Root Tip ofFrontiers in plant science · 2022Article
- CsbZIP2-miR9748-CsNPF4.4 Module Mediates High Temperature Tolerance of Cucumber Through Jasmonic Acid Pathway.Frontiers in plant science · 2022Article
- Potential transceptor AtNRT1.13 modulates shoot architecture and flowering time in a nitrate-dependent manner.The Plant cell · 2021Article
- Genome-wide identification and expression analyses of nitrate transporter family genes in wild soybean (Glycine soja).Journal of applied genetics · 2020Article
- The intersection of nitrogen nutrition and water use in plants: new paths toward improved crop productivity.Journal of experimental botany · 2020Review
- Nitrate in 2020: Thirty Years from Transport to Signaling Networks.The Plant cell · 2020Review
- The physiological mechanism underlying root elongation in response to nitrogen deficiency in crop plants.Planta · 2020Review
- TaANR1-TaBG1 and TaWabi5-TaNRT2s/NARs Link ABA Metabolism and Nitrate Acquisition in Wheat Roots.Plant physiology · 2020Article
- Drought Stress Responses and Resistance in Plants: From Cellular Responses to Long-Distance Intercellular Communication.Frontiers in plant science · 2020Review
- Functional Characterization of the Arabidopsis Abscisic Acid Transporters NPF4.5 and NPF4.6 in Xenopus Oocytes.Frontiers in plant science · 2020Article
- Disruption of the Lotus japonicus transporter LjNPF2.9 increases shoot biomass and nitrate content without affecting symbiotic performances.BMC plant biology · 2019Article
- MtABCG20 is an ABA exporter influencing root morphology and seed germination of Medicago truncatula.The Plant journal : for cell and molecular biology · 2019Article
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Authors and funding
11 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Elongation of the primary root during postgermination of Medicago truncatula seedlings is a multigenic trait that is responsive to exogenous nitrate. A quantitative genetic approach suggested the involvement of the nitrate transporter MtNPF6.8 (for Medicago truncatula NITRATE TRANSPORTER1/PEPTIDE TRANSPORTER Family6.8) in the inhibition of primary root elongation by high exogenous nitrate. In this study, the inhibitory effect of nitrate on primary root elongation, via inhibition of elongation of root cortical cells, was abolished in npf6.8 knockdown lines. Accordingly, we propose that MtNPF6.8 mediates nitrate inhibitory effects on primary root growth in M. truncatula. pMtNPF6.8:GUS promoter-reporter gene fusion in Agrobacterium rhizogenes-generated transgenic roots showed the expression of MtNPF6.8 in the pericycle region of primary roots and lateral roots, and in lateral root primordia and tips. MtNPF6.8 expression was insensitive to auxin and was stimulated by abscisic acid (ABA), which restored the inhibitory effect of nitrate in npf6.8 knockdown lines. It is then proposed that ABA acts downstream of MtNPF6.8 in this nitrate signaling pathway. Furthermore, MtNPF6.8 was shown to transport ABA in Xenopus spp. oocytes, suggesting an additional role of MtNPF6.8 in ABA root-to-shoot translocation. (15)NO3(-)-influx experiments showed that only the inducible component of the low-affinity transport system was affected in npf6.8 knockdown lines. This indicates that MtNPF6.8 is a major contributor to the inducible component of the low-affinity transport system. The short-term induction by nitrate of the expression of Nitrate Reductase1 (NR1) and NR2 (genes that encode two nitrate reductase isoforms) was greatly reduced in the npf6.8 knockdown lines, supporting a role of MtNPF6.8 in the primary nitrate response in M. truncatula.
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