Trial reportMedical oncology (Northwood, London, England)2014
MR imaging in hepatocellular carcinoma: correlations between MRI features and molecular marker VEGF.
Trial report in Medical oncology (Northwood, London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- A Nomogram Based on MRI Visual Decision Tree to Evaluate Vascular Endothelial Growth Factor in Hepatocellular Carcinoma.Journal of magnetic resonance imaging : JMRI · 2025Article
- A correlative study between IVIM-DWI parameters and VEGF and MMPs expression in hepatocellular carcinoma.Quantitative imaging in medicine and surgery · 2023Article
- Combined clinical features and MRI parameters for the prediction of VEGFR2 in hepatocellular carcinoma patients.Frontiers in oncology · 2022Article
- Association Between VEGF Expression and Diffusion Weighted Imaging in Several Tumors-A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2019Article
- Prediction of sorafenib treatment-related gene expression for hepatocellular carcinoma: preoperative MRI and histopathological correlation.European radiology · 2019Article
- Hepatocellular Carcinoma and Diffusion-Weighted MRI: Detection and Evaluation of Treatment Response.Journal of Cancer · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this paper was to investigate the correlations between magnetic resonance imaging (MRI) features and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC). Thirty-six patients with HCC included in this study underwent dynamic contrast-enhanced MR imaging and diffusion-weighted MR imaging. Signal intensity characteristics of HCCs were reviewed independently by two experienced radiologists. ADC maps were automatically computed. VEGF expression was evaluated by immunohistochemical staining. The grades of the VEGF expression were correlated inversely with the ADC values of the HCCs (r = -0.435, p = 0.008). Intensity heterogeneity correlated with VEGF expression (r = 0.571, p = 0.039). There is a significant correlation between the intensity of arterial enhancement and VEGF expression (r = -0.386, p = 0.02). However, no correlation was found between the VEGF grades and the intensity of enhancement in the hepatic portal venous and late phases, as well as equilibrium phase. Our results indicate that ADC value on DW-MRI, the signal intensity in arterial phase and intensity heterogeneity correlate with the degree of VEGF expression in hepatocellular carcinomas.
Indexed as
Identifiers
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Registered trials
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