ArticleCNS neuroscience & therapeutics2014
Allogeneic head and body reconstruction: mouse model.
Article in CNS neuroscience & therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Is it time to perform the first human head transplant? Comment on the CSA (CephaloSomatic Ansatomisis) paper by Ren, Canavero, and colleagues.Surgical neurology international · 2018Article
- Is it time to perform the first human head transplant? Comment on the CSA (cephalosomatic anastomosis) paper by Ren, Canavero, and colleagues.Surgical neurology international · 2018Article
- A cross-circulated bicephalic model of head transplantation.CNS neuroscience & therapeutics · 2017Article
- Surgical, ethical, and psychosocial considerations in human head transplantation.International journal of surgery (London, England) · 2017Review
- Severe traumatic hemorrhagic shock induces compromised immune barrier function of the mesenteric lymph node leading to an increase in intestinal bacterial translocation.American journal of translational research · 2017Article
- First cephalosomatic anastomosis in a human model.Surgical neurology international · 2017Article
- The history of head transplantation: a review.Acta neurochirurgica · 2016Review
- PEG-assisted reconstruction of the cervical spinal cord in rats: effects on motor conduction at 1 h.Spinal cord · 2016Article
- The Age of Head Transplants.CNS neuroscience & therapeutics · 2016Article
- Human head transplantation. Where do we stand and a call to arms.Surgical neurology international · 2016Article
- Head Transplantation in Mouse Model.CNS neuroscience & therapeutics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThere is still no effective way to save a surviving healthy mind when there is critical organ failure in the body. The next frontier in CTA is allo-head and body reconstruction (AHBR), and just as animal models were key in the development of CTA, they will be crucial in establishing the procedures of AHBR for clinical translation. METHODS AND
resultsOur approach, pioneered in mice, involves retaining the donor brain stem and transplanting the recipient head. Our preliminary data in mice support that this allows for retention of breathing and circulatory function. Critical aspects of the current protocol include avoiding cerebral ischemia through cross-circulation (donor to recipient) and retaining the donor brain stem. Successful clinical translation of AHBR will become a milestone of medical history and potentially could save millions of people.
conclusionsThis experimental study has confirmed a method to avoid cerebral ischemia during the surgery and solved an important part of the problem of how to accomplish long-term survival after transplantation and preservation of the donor brain stem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.