ArticleVirology journal2014
Transmission of H7N9 influenza virus in mice by different infective routes.
Article in Virology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Experimental Infection of Rats with Influenza A Viruses: Implications for Murine Rodents in Influenza A Virus Ecology.Viruses · 2025Article
- Quantitative measurement of influenza virus transmission in animal model: an overview of current state.Biophysical reviews · 2023Review
- Influenza H7N9 virus disrupts the monolayer human brain microvascular endothelial cells barrier in vitro.Virology journal · 2023Article
- Correction to: Transmission of H7N9 influenza virus in mice by different infective routes.Virology journal · 2021Article
- Murine Model for the Study of Influenza D Virus.Journal of virology · 2020Article
- The development and application of Laboratory Animal Science in China.Animal models and experimental medicine · 2018Article
- Role of H7 hemagglutinin in murine infectivity of influenza viruses following ocular inoculation.Virology · 2017Article
- Mammalian Pathogenesis and Transmission of H7N9 Influenza Viruses from Three Waves, 2013-2015.Journal of virology · 2016Article
- Avian Influenza Viruses, Inflammation, and CD8(+) T Cell Immunity.Frontiers in immunology · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOn 19 February 2013, the first patient infected with a novel influenza A H7N9 virus from an avian source showed symptoms of sickness. More than 349 laboratory-confirmed cases and 109 deaths have been reported in mainland China since then. Laboratory-confirmed, human-to-human H7N9 virus transmission has not been documented between individuals having close contact; however, this transmission route could not be excluded for three families. To control the spread of the avian influenza H7N9 virus, we must better understand its pathogenesis, transmissibility, and transmission routes in mammals. Studies have shown that this particular virus is transmitted by aerosols among ferrets.
methodsTo study potential transmission routes in animals with direct or close contact to other animals, we investigated these factors in a murine model.
resultsViable H7N9 avian influenza virus was detected in the upper and lower respiratory tracts, intestine, and brain of model mice. The virus was transmissible between mice in close contact, with a higher concentration of virus found in pharyngeal and ocular secretions, and feces. All these biological materials were contagious for naïve mice.
conclusionsOur results suggest that the possible transmission routes for the H7N9 influenza virus were through mucosal secretions and feces.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.