ArticleEnvironmental science and pollution research international2015
Urinary thiocyanate concentrations are associated with adult cancer and lung problems: US NHANES, 2009-2012.
Article in Environmental science and pollution research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Modulation of chemokine secretion and oxidative stressFrontiers in endocrinology · 2026Article
- Association of urinary perchlorate, nitrate, and thiocyanate concentrations with pulmonary function in children aged 6-19 years.BMC public health · 2025Article
- SERS sensing for cancer biomarker: Approaches and directions.Bioactive materials · 2024Review
- The association between environmental exposure to perchlorate, nitrate, and thiocyanate and all-cause and cause-specific mortality.Environmental science and pollution research international · 2022Article
- Raman Spectroscopy: A Potential Diagnostic Tool for Oral Diseases.Frontiers in cellular and infection microbiology · 2022Review
- The Role of Thiocyanate in Modulating Myeloperoxidase Activity during Disease.International journal of molecular sciences · 2020Review
- Detecting Mercury (II) and Thiocyanate Using "Turn-on" Fluorescence of Graphene Quantum Dots.Journal of fluorescence · 2020Article
- Surface-enhanced Raman spectroscopy (SERS) investigations of saliva for oral cancer diagnosis.Lasers in medical science · 2020Article
- Exposure to perchlorate, nitrate and thiocyanate, and prevalence of diabetes mellitus.International journal of epidemiology · 2017Article
- Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma.The Journal of biological chemistry · 2016Article
- Urinary heavy metals, phthalates, perchlorate, nitrate, thiocyanate, hydrocarbons, and polyfluorinated compounds are associated with adult hearing disturbance: USA NHANES, 2011–2012.Environmental science and pollution research international · 2015Article
- Urinary heavy metals, phthalates and polyaromatic hydrocarbons independent of health events are associated with adult depression: USA NHANES, 2011-2012.Environmental science and pollution research international · 2015Article
- Urinary arsenic, heavy metals, phthalates, pesticides, polyaromatic hydrocarbons but not parabens, polyfluorinated compounds are associated with self-rated health: USA NHANES, 2011-2012.Environmental science and pollution research international · 2015Article
- Arsenic, heavy metals, phthalates, pesticides, hydrocarbons and polyfluorinated compounds but not parabens or phenols are associated with adult remembering condition: US NHANES, 2011-2012.Environmental science and pollution research international · 2015Article
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Links between environmental chemicals and human health have emerged but the effects from perchlorate, nitrate and thiocyanate were unclear. Therefore, it was aimed to study the relationships of urinary perchlorate, nitrate and thiocyanate concentrations and adult health conditions in a national and population-based study. Data was retrieved from US National Health and Nutrition Examination Surveys, 2009-2012, including demographics, blood pressure readings, self-reported health conditions and urinary perchlorate, nitrate and thiocyanate concentrations. Analyses included chi-square test, t test survey-weighted logistic regression models and population attributable risk estimation. There were no clear associations between urinary perchlorate concentrations and adult health conditions, although people with hearing loss and diabetes could be at the borderline risk. Urinary thiocyanate concentrations were significantly associated with emphysema (odds ratio (OR) 2.70 95% confidence intervals (CI) 1.91-3.82, P < 0.001), cancer (OR 1.21 95%CI 1.06-1.39, P = 0.008), chronic bronchitis (OR 1.23 95%CI 1.10-1.52, P = 0.003), wheezing (OR 1.24 95%CI 1.05-1.46, P = 0.011), coughing (OR 1.19 95%CI 1.03-1.37, P = 0.018) and sleep complaints (OR 1.14 95%CI 1.02-1.26, P = 0.019). The population attributable risks accounted for 3.3% (1.8-5.3%), 1.9% (0.6-3.5%), 1.2% (0.5-2.6%), 2.2% (0.5-4.1%), 1.8% (0.3-6.2%) and 1.3% (0.2-2.4%) for emphysema, cancer, chronic bronchitis, wheezing, coughing and sleep complaints, respectively. In addition, there was an inverse association observed between urinary nitrate level and heart failure. This is for the first time observing significant risk effects of urinary thiocyanate concentrations on adult cancer and lung problems, although the causality cannot be established. Elimination of such environmental chemical in humans should be included in future health policy and intervention programs.
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