Evidence map›Paper›PMID 25367540›Full record

ArticlePediatrics2014

Early developmental outcomes of children with congenital HHV-6 infection.

Mary T Caserta, Caroline B Hall, Richard L Canfield, Philip Davidson, Gerry Lofthus, Kenneth Schnabel, Jennifer Carnahan, Lynne Shelley, Hongyue Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mary T CasertaDepartments of Pediatrics, mary_caserta@urmc.rochester.edu.
Caroline B HallDepartments of Pediatrics, Medicine.
Richard L CanfieldDivision of Nutritional Sciences, Cornell University, Ithaca, New York.
Philip DavidsonBehavioral Pediatrics and Developmental Disabilities, and.
Gerry LofthusMedicine.
Kenneth SchnabelDepartments of Pediatrics.
Jennifer CarnahanDepartments of Pediatrics.
Lynne ShelleyDepartments of Pediatrics.
Hongyue WangBiostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York; and.
Pediatrics and Genetics · USCornell University · USUniversity of Rochester Medical Center · US

Funding

YOHIMBINE CHALLENGE IN PARKINSONIAN PATIENTS WITH PANIC DISORDERM01RR000044 · NCRR · UNIVERSITY OF ROCHESTER · PI GUZICK, DAVID S · 1985 to 2006
$13.8M
Congenital HHV6 Infection: Characteristics and OutcomeR01HD044430 · NICHD · UNIVERSITY OF ROCHESTER · PI HALL, CAROLINE BREESE · 2003 to 2007
$3.1M
NCRR NIH HHS 5 MO1 RR00044NCRR NIH HHS M01 RR000044NICHD NIH HHS R01 HD044430NICHD NIH HHS R01 HD 44430-01
6 · The paper itself

Abstract

objectiveThe goal of this study was to determine if congenital human herpesvirus-6 (HHV-6) infection influences early neurodevelopment.

methodsWe enrolled 57 newborns with HHV-6 congenital infection and 242 control newborns without congenital infection into a prospective, double-blind study with 4 visits between 4 and 30 months of age. Assessments included the Fagan Test of Infant Intelligence, the Visual Expectation Paradigm, and the Mental Development Index (MDI) of the Bayley Scales of Infant Development II. Newborn audiology screening and follow-up audiology examinations were completed at 12 to 24 months.

resultsNo differences were noted in baseline characteristics between infants with HHV-6 congenital infection and control infants. No clinical syndrome due to congenital infection with HHV-6 was evident at birth. No differences were identified on the Fagan Test of Infant Intelligence or the Visual Expectation Paradigm between the two groups. In 39 infants with HHV-6 congenital infection, the mean ± SD Bayley Scale of Infant Development II MDI score was 103.4 ± 8.9 at 12 months of age. The matched control infants had a mean score of 105.4 ± 12.4. After controlling for covariates, HHV-6 congenital infection was associated with lower scores on the Bayley Scale of Infant Development II MDI at 12 months of age (mean difference: 4.3 [95% confidence interval: 0.4 to 8.1]; P = .03) compared with infants without HHV-6 congenital infection.

conclusionsCongenital HHV-6 infection may have a detrimental effect on neurodevelopment at 12 months of age and requires further study given that congenital infection with HHV-6 is present in ∼1 in every 101 births.

Indexed as

Herpesvirus 6, HumanAnticipation, PsychologicalAttentionDevelopmental DisabilitiesDouble-Blind MethodFemaleFollow-Up StudiesHumansInfantInfant, NewbornIntelligenceMaleMemory, Short-TermNeuropsychological TestsPattern Recognition, VisualProspective Studiescongenital HHV-6 infectionneurodevelopment

Identifiers

PMID25367540
PMCPMC4243068
OpenAlexW1966901094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.