ReviewCell and tissue research2015
The roles and regulation of Polycomb complexes in neural development.
Review in Cell and tissue research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 72 citations in OpenAlex.
- Polycomb Repressive Complex 2 (PRC2): A Context-Dependent Epigenetic Regulator of Brain Aging.Biomolecules · 2026Review
- Article
- Ezh2 Loss-of-Function Alters Zebrafish Cerebellum Development.International journal of molecular sciences · 2025Article
- Aging by the clock and yet without a program.Nature aging · 2025Review
- Abnormal H3K4 enzyme catalytic activity and neuronal morphology caused by ASH1L mutations in individuals with Tourette syndrome.European child & adolescent psychiatry · 2024Article
- Hyperactivating EZH2 to augment H3K27me3 levels in regulatory T cells enhances immune suppression by driving early effector differentiation.Cell reports · 2024Article
- Polycomb repressive complex 2 is critical for mouse cortical glutamatergic neuron development.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Lineage specification in glioblastoma is regulated by METTL7B.Cell reports · 2024Article
- Epigenetic Dysregulation inInternational journal of molecular sciences · 2023Review
- Acquisition of neural fate by combination of BMP blockade and chromatin modification.iScience · 2023Article
- Computational analysis of crosstalk between transcriptional regulators and RNA-binding proteins suggests mutual regulation of polycomb proteins and SRSF1 influencing adult hippocampal neurogenesis.Discover mental health · 2023Article
- TFIIIC as a Potential Epigenetic Modulator of Histone Acetylation in Human Stem Cells.International journal of molecular sciences · 2023Article
- Non-coding RNAs associated with Prader-Willi syndrome regulate transcription of neurodevelopmental genes in human induced pluripotent stem cells.Human molecular genetics · 2023Article
- The role of histone methyltransferases in neurocognitive disorders associated with brain size abnormalities.Frontiers in neuroscience · 2023Review
- Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain.Epigenetics & chromatin · 2022Review
- PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons.Science advances · 2022Article
- Nutrient sensitive proteinLife science alliance · 2022Article
- Counteracting epigenetic mechanisms regulate the structural development of neuronal circuitry in human neurons.Molecular psychiatry · 2022Article
- Soma-to-germline transformation in chromatin-linked neurodevelopmental disorders?The FEBS journal · 2022Review
- EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of Neuronal Differentiation.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the developing mammalian nervous system, common progenitors integrate both cell extrinsic and intrinsic regulatory programs to produce distinct neuronal and glial cell types as development proceeds. This spatiotemporal restriction of neural progenitor differentiation is enforced, in part, by the dynamic reorganization of chromatin into repressive domains by Polycomb repressive complexes, effectively limiting the expression of fate-determining genes. Here, we review the distinct roles that Polycomb repressive complexes play during neurogenesis and gliogenesis, while also highlighting recent work describing the molecular mechanisms that govern their dynamic activity in neural development. Further investigation of the way in which Polycomb complexes are regulated in neural development will enable more precise manipulation of neural progenitor differentiation facilitating the efficient generation of specific neuronal and glial cell types for many biological applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.