ArticleInternational urology and nephrology2015
Changes in glomerular filtration rate after donation in living kidney donors: a single-center cohort study.
Article in International urology and nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Prediction of post-donation renal function using machine learning techniques and conventional regression models in living kidney donors.Journal of nephrology · 2024Article
- Renal function outcomes in living kidney donors in a transplant center in Colombia.SAGE open medicine · 2024Article
- Acute kidney injury and the compensation of kidney function after nephrectomy in living donation.World journal of transplantation · 2022Review
- Evaluation of postoperative kidney function after administration of 6% hydroxyethyl starch during living-donor nephrectomy for transplantation.Journal of anesthesia · 2021Article
- Prediction model of compensation for contralateral kidney after living-donor donation.BMC nephrology · 2019Article
- Baseline living-donor kidney volume and function associate with 1-year post-nephrectomy kidney function.Clinical transplantation · 2019Article
- External validation of a proposed prognostic model for the prediction of 1-year postoperative eGFR after living donor nephrectomy.International urology and nephrology · 2017Article
- Predictive model of 1-year postoperative renal function after living donor nephrectomy.International urology and nephrology · 2017Article
- Follow-up rates of living kidney donor in Japan: A single center study.Indian journal of nephrologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeA number of studies have reported on decline in glomerular filtration rate (GFR) after donation in Japanese living kidney donors. The purpose of the present study was to examine the clinicopathological factors associated with changes in GFR after donation in living kidney donors.
methodsWe reviewed the charts of living kidney donors (n = 294) and monitored estimated GFR (eGFR) values from the time of 0-h kidney biopsy until 3 years after donation. We assessed donor age, gender, body mass index, blood pressure, urinalysis, and several other clinical parameters including the severity of glomerulosclerosis and arteriosclerosis.
resultsThe grade of arteriosclerosis in 0-h biopsy specimens was higher in the older donor group (57-76 years) than in the younger donor group (30-56 years). Mean donor eGFR at the time of the donation was 80.1 ± 13.6 ml/min/1.73 m(2). Most of the living kidney donors in this study developed stage 3 chronic kidney disease (CKD). The mean changes in eGFR at 1-3 years after donation showed a steady state that was distinct from the generally accepted notion that GFR declines with age. Multivariate regression analyses showed that the changes in eGFR were negatively associated with age (r = -0.21, P < 0.001) and preoperative eGFR (r = -0.18, P < 0.001), but not associated with the grade of glomerulosclerosis and arteriosclerosis.
conclusionDonor age and pre-GFR at the time of nephrectomy were associated with decline in kidney function in living kidney donors after donation. Most of the donors developed stage 3 CKD within 3 years after donation but without subsequent progression, at least for several years.
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