ArticleMolecular genetics and genomics : MGG2015
The rice (Oryza sativa L.) LESION MIMIC RESEMBLING, which encodes an AAA-type ATPase, is implicated in defense response.
Article in Molecular genetics and genomics : MGG, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 67 citations in OpenAlex.
- Functional Characterization of Rice Spotted-Leaf MutantPlants (Basel, Switzerland) · 2025Article
- Lesion Mimic Mutant: An Ideal Genetic Material for Deciphering the Balance Between Plant Immunity and Growth.Rice (New York, N.Y.) · 2025Review
- All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Phytoalexin deficient 4 is associated with the lesion mimic trait in watermelon clalm mutant (Citrullus lanatus).BMC plant biology · 2025Article
- Marker-Assisted Selection of Jacalin-Related Lectin GenesInternational journal of molecular sciences · 2024Article
- Article
- A single amino acid substitution in the AAA-type ATPase LRD6-6 activates immune responses but decreases grain quality in rice.Frontiers in plant science · 2024Article
- High-Density Linkage Maps from Japanese RicePlants (Basel, Switzerland) · 2023Article
- Engineering plant immune circuit: walking to the bright future with a novel toolbox.Plant biotechnology journal · 2023Review
- Natural immunity stimulation using ELICE16INDURES® plant conditioner in field culture of soybean.Heliyon · 2023Article
- Ubiquitin-Specific Protease 2 (OsUBP2) Negatively Regulates Cell Death and Disease Resistance in Rice.Plants (Basel, Switzerland) · 2022Article
- Genetic mapping of sorghum resistance to an Illinois isolate of Colletotrichum sublineola.The plant genome · 2022Article
- Advances in the Genetic Basis and Molecular Mechanism of Lesion Mimic Formation in Rice.Plants (Basel, Switzerland) · 2022Review
- A Single Amino Acid Substitution in MIL1 Leads to Activation of Programmed Cell Death and Defense Responses in Rice.International journal of molecular sciences · 2022Article
- The Rice Malectin Regulates Plant Cell Death and Disease Resistance by Participating in Glycoprotein Quality Control.International journal of molecular sciences · 2022Article
- Rice Lesion Mimic Gene Cloning and Association Analysis for Disease Resistance.Current issues in molecular biology · 2022Review
- Disruption ofInternational journal of molecular sciences · 2022Article
- Characterization and fine mapping of a lesion mimic mutant (Lm5) with enhanced stripe rust and powdery mildew resistance in bread wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- A Phosphoproteomics Study of the SoybeanFrontiers in plant science · 2022Article
- Identification and fine mapping of lesion mimic mutantBreeding science · 2021Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lesion mimic mutants (LMMs) provide a useful tool to study defense-related programmed cell death (PCD) in plants. Although a number of LMMs have been identified in multiple species, most of the candidate genes are yet to be isolated. Here, we report the identification and characterization of a novel rice (Oryza sativa L.) lesion mimic resembling (lmr) mutant, and cloning of the corresponding LMR gene. The LMR locus was initially delineated to 1.2 Mb region on chromosome 6, which was further narrowed down to 155-kb using insertions/deletions (INDELs) and cleavage amplified polymorphic sequence markers developed in this study. We sequenced the open reading frames predicted within the candidate genomic region, and identified a G-A base substitution causing a premature translation termination in a gene that encodes an ATPase associated with various cellular activities type (AAA-type) protein. RNA interference transgenic lines with reduced LMR transcripts exhibited the lesion mimic phenotype similar to that of lmr plants. Furthermore, expression of the wild-type LMR in the mutant background complemented the lesion phenotype, confirming that the mutation identified in LMR is responsible for the mutant phenotype. The pathogenesis-related (PR) genes PBZ1 and PR1 were induced in lmr, which also showed enhanced resistance to rice blast (Magnaporthe oryzae) and bacterial blight (Xanthomonas oryzae pv. oryzae), suggesting LMR is a negative regulator of cell death in rice. The identification of lmr and cloning of the corresponding LMR gene provide an additional resource for the study of PCD in plants.
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