ArticleChemphyschem : a European journal of chemical physics and physical chemistry2014
In situ and ex situ low-field NMR spectroscopy and MRI endowed by SABRE hyperpolarization.
Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Open-Source Multinuclear Low-Field Preclinical MRI Scanner.NMR in biomedicine · 2026Article
- Article
- Development of a fully automated workstation for conducting routine SABRE hyperpolarization.Scientific reports · 2024Article
- Toward Next-Generation Molecular Imaging with a Clinical Low-Field (0.064 T) Point-of-Care MRI Scanner.Analytical chemistry · 2024Article
- Molecules, Up Your Spins!Molecules (Basel, Switzerland) · 2024Article
- LC-Photo-CIDNP hyperpolarization of biomolecules bearing a quasi-isolated spin pair: Magnetic-Field dependence via a rapid-shuttling device.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2024Article
- Real-Time Reaction Monitoring of Azide-Alkyne Cycloadditions Using Benchtop NMR-Based Signal Amplification by Reversible Exchange (SABRE).ACS measurement science au · 2023Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents.International journal of molecular sciences · 2023Article
- Selective Isotope Labeling and LC-Photo-CIDNP Enable NMR Spectroscopy at Low-Nanomolar Concentration.Journal of the American Chemical Society · 2022Article
- Quasi-continuous production of highly hyperpolarized carbon-13 contrast agents every 15 seconds within an MRI system.Communications chemistry · 2022Article
- Quantifying the effects of quadrupolar sinks viaChemical communications (Cambridge, England) · 2020Article
- SABRE polarized low field rare-spin spectroscopy.The Journal of chemical physics · 2020Article
- Automated pneumatic shuttle for magnetic field cycling and parahydrogen hyperpolarized multidimensional NMR.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- In Situ SABRE Hyperpolarization with Earth's Field NMR Detection.Molecules (Basel, Switzerland) · 2019Article
- Multiple Quantum Coherences Hyperpolarized at Ultra-Low Fields.Chemphyschem : a European journal of chemical physics and physical chemistry · 2019Article
- A versatile synthetic route to the preparation ofJournal of labelled compounds & radiopharmaceuticals · 2019Article
- SQUID-based ultralow-field MRI of a hyperpolarized material using signal amplification by reversible exchange.Scientific reports · 2019Article
- Selective hyperpolarization of heteronuclear singlet states via pulsed microtesla SABRE.The Journal of chemical physics · 2019Article
- Article
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Authors and funding
13 authors.
Funding
Abstract
By using 5.75 and 47.5 mT nuclear magnetic resonance (NMR) spectroscopy, up to 10(5)-fold sensitivity enhancement through signal amplification by reversible exchange (SABRE) was enabled, and subsecond temporal resolution was used to monitor an exchange reaction that resulted in the buildup and decay of hyperpolarized species after parahydrogen bubbling. We demonstrated the high-resolution low-field proton magnetic resonance imaging (MRI) of pyridine in a 47.5 mT magnetic field endowed by SABRE. Molecular imaging (i.e. imaging of dilute hyperpolarized substances rather than the bulk medium) was conducted in two regimes: in situ real-time MRI of the reaction mixture (in which pyridine was hyperpolarized), and ex situ MRI (in which hyperpolarization decays) of the liquid hyperpolarized product. Low-field (milli-Tesla range, e.g. 5.75 and 47.5 mT used in this study) parahydrogen-enhanced NMR and MRI, which are free from the limitations of high-field magnetic resonance (including susceptibility-induced gradients of the static magnetic field at phase interfaces), potentially enables new imaging applications as well as differentiation of hyperpolarized chemical species on demand by exploiting spin manipulations with static and alternating magnetic fields.
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