ArticleJournal of immunology (Baltimore, Md. : 1950)2014
Polarized granzyme release is required for antigen-driven transendothelial migration of human effector memory CD4 T cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Transendothelial Migration of Human B Cells: Chemokine versus Antigen.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Mechanisms Regulating T Cell-Endothelial Cell Interactions.Cold Spring Harbor perspectives in medicine · 2022Review
- Costimulators expressed on human endothelial cells modulate antigen-dependent recruitment of circulating T lymphocytes.Frontiers in immunology · 2022Article
- The number of donor HLA-derived T cell epitopes available for indirect antigen presentation determines the risk for vascular rejection after kidney transplantation.Frontiers in immunology · 2022Article
- Divergent TCR-Initiated Calcium Signals Govern Recruitment versus Activation of Human Alloreactive Effector Memory T Cells by Endothelial Cells.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- CD4Frontiers in immunology · 2018Article
- Fingolimod alters the transcriptome profile of circulating CD4+ cells in multiple sclerosis.Scientific reports · 2017Article
- Antigen Presentation by Vascular Cells.Frontiers in immunology · 2017Review
- B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Significant Differences in Antigen-Induced Transendothelial Migration of Human CD8 and CD4 T Effector Memory Cells.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation.Mediators of inflammation · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Human effector memory CD4 T cells may transmigrate across endothelial cell (EC) monolayers either in response to inflammatory chemokines or in response to TCR recognition of Ag presented on the surface of the EC. The kinetics, morphologic manifestations, and molecular requirements of chemokine- and TCR-driven transendothelial migration (TEM) differ significantly. In this study, we report that, whereas the microtubule organizing center (MTOC) and cytosolic granules follow the nucleus across the endothelium in a uropod during chemokine-driven TEM, MTOC reorientation to the contact region between the T cell and the EC, accompanied by dynein-driven transport of granzyme-containing granules to and exocytosis at the contact region, are early events in TCR-driven, but not chemokine-driven TEM. Inhibitors of either granule function or granzyme proteolytic activity can arrest TCR-driven TEM, implying a requirement for granule discharge in the process. In the final stages of TCR-driven TEM, the MTOC precedes, rather than follows, the nucleus across the endothelium. Thus, TCR-driven TEM of effector memory CD4 T cells appears to be a novel process that more closely resembles immune synapse formation than it does conventional chemotaxis.
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Registered trials
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