ArticleMolecular microbiology2015
Determinants governing ligand specificity of the Vibrio harveyi LuxN quorum-sensing receptor.
Article in Molecular microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Bacterial Sentience Is Determined by the Stochastic, Chaotic, and Deterministic Behavior of Cytoplasmic Particles.Current issues in molecular biology · 2026Review
- A Geneticist Transcribing the Chemical Language of Bacteria.Israel journal of chemistry · 2023Article
- Natural and synthetic inhibitors of a phage-encoded quorum-sensing receptor affect phage-host dynamics in mixed bacterial communities.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Signal Transduction Network Principles Underlying Bacterial Collective Behaviors.Annual review of microbiology · 2022Review
- Inverse regulation ofeLife · 2021Article
- Saccharomyces cerevisiae RequiresmBio · 2021Article
- A Bacterial Tower of Babel: Quorum-Sensing Signaling Diversity and Its Evolution.Annual review of microbiology · 2020Review
- The Marine Bacterium Shewanella woodyi Produces CMicrobial ecology · 2020Article
- Mechanism underlying autoinducer recognition in theThe Journal of biological chemistry · 2020Article
- Global H-NS counter-silencing by LuxR activates quorum sensing gene expression.Nucleic acids research · 2020Article
- The Probiotic Bacterium Phaeobacter inhibens Downregulates Virulence Factor Transcription in the Shellfish Pathogen Vibrio coralliilyticus byApplied and environmental microbiology · 2019Article
- Structural determinants driving homoserine lactone ligand selection in theProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Specificity and complexity in bacterial quorum-sensing systems.FEMS microbiology reviews · 2016Review
- Quorum sensing signal-response systems in Gram-negative bacteria.Nature reviews. Microbiology · 2016Review
- A Host-Produced Autoinducer-2 Mimic Activates Bacterial Quorum Sensing.Cell host & microbe · 2016Article
- Facultative cheating supports the coexistence of diverse quorum-sensing alleles.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A Social Medium: ASM's 5th Cell-Cell Communication in Bacteria Meeting in Review.Journal of bacteriology · 2015Article
- Exploiting Quorum Sensing Interfering Strategies in Gram-Negative Bacteria for the Enhancement of Environmental Applications.Frontiers in microbiology · 2015Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Quorum sensing is a process of bacterial cell-cell communication that relies on the production, release and receptor-driven detection of extracellular signal molecules called autoinducers. The quorum-sensing bacterium Vibrio harveyi exclusively detects the autoinducer N-((R)-3-hydroxybutanoyl)-L-homoserine lactone (3OH-C4 HSL) via the two-component receptor LuxN. To discover the principles underlying the exquisite selectivity LuxN has for its ligand, we identified LuxN mutants with altered specificity. LuxN uses three mechanisms to verify that the bound molecule is the correct ligand: in the context of the overall ligand-binding site, His210 validates the C3 modification, Leu166 surveys the chain-length and a strong steady-state kinase bias imposes an energetic hurdle for inappropriate ligands to elicit signal transduction. Affinities for the LuxN kinase on and kinase off states underpin whether a ligand will act as an antagonist or an agonist. Mutations that bias LuxN to the agonized, kinase off, state are clustered in a region adjacent to the ligand-binding site, suggesting that this region acts as the switch that triggers signal transduction. Together, our analyses illuminate how a histidine sensor kinase differentiates between ligands and exploits those differences to regulate its signaling activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.