ArticleBrain : a journal of neurology2014
Reduced Purkinje cell dendritic arborization and loss of dendritic spines in essential tremor.
Article in Brain : a journal of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.
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Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Pooled it
- Imaging the Pathophysiology of Essential Tremor-A Systematic Review.Frontiers in neurology · 2021Pooled it
- Differential metabolic and cellular brain regional susceptibility in adult rats with chronic liver disease.Metabolic brain disease · 2026Article
- A Streamlined Workflow for Purkinje Cell Labeling and High-Resolution Analyses of Dendrites and Spines in Mice.eNeuro · 2026Article
- An Investigation of Heterogeneity in Cerebellar Cortical Pathology Across Essential Tremor Cases: A Cluster Analysis.Cerebellum (London, England) · 2026Article
- Essential Tremor Cases with Subtle Cerebellar Pathology: A Systematic Study of Postmortem Cerebellar Changes.Cerebellum (London, England) · 2026Article
- Modulation of Lingo-1 and NMDA receptor expression by memantine and vitamin D3 co-therapy attenuates motor and non-motor symptoms in essential tremor.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Comparative study of the pathology in anterior versus posterior hemispheric regions of cerebellum in essential tremor and controls.Acta neuropathologica · 2026Article
- GABAergic neuronal dysfunction underlies tremor in spinocerebellar ataxia 3.Disease models & mechanisms · 2025Article
- The cerebellar involvement in essential tremor: the connecting roads.Arquivos de neuro-psiquiatria · 2025Review
- Loss-of-function variations in solute carrier family 38 member 6 are associated with essential tremor.Signal transduction and targeted therapy · 2025Article
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- Article
- Histological features of the Purkinje neurons of the Albino rat (Anatomy & cell biology · 2025Article
- Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer's disease and primary age-related tauopathy.Acta neuropathologica · 2025Article
- The spiny relationship between parallel fibers, climbing fibers, and Purkinje cells.Frontiers in physiology · 2025Review
- Clinical Heterogeneity of Essential Tremor: Understanding Neural Substrates of Action Tremor Subtypes.Cerebellum (London, England) · 2024Review
- Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer's disease and primary age-related tauopathy.bioRxiv : the preprint server for biology · 2024Article
- Pathologically based criteria to distinguish essential tremor from controls: analyses of the human cerebellum.Annals of clinical and translational neurology · 2024Article
- Reduced Bergmann glial process terminations and lateral appendages in essential tremor.Annals of clinical and translational neurology · 2024Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Based on accumulating post-mortem evidence of abnormalities in Purkinje cell biology in essential tremor, we hypothesized that regressive changes in dendritic morphology would be apparent in the Purkinje cell population in essential tremor cases versus age-matched controls. Cerebellar cortical tissue from 27 cases with essential tremor and 27 age-matched control subjects was processed by the Golgi-Kopsch method. Purkinje cell dendritic anatomy was quantified using a Neurolucida microscopic system interfaced with a motorized stage. In all measures, essential tremor cases demonstrated significant reductions in dendritic complexity compared with controls. Median values in essential tremor cases versus controls were: 5712.1 versus 10 403.2 µm (total dendrite length, P=0.01), 465.9 versus 592.5 µm (branch length, P=0.01), 22.5 versus 29.0 (maximum branch order, P=0.001), and 165.3 versus 311.7 (number of terminations, P=0.008). Furthermore, the dendritic spine density was reduced in essential tremor cases (medians=0.82 versus 1.02 µm(-1), P=0.03). Our demonstration of regressive changes in Purkinje cell dendritic architecture and spines in essential tremor relative to control brains provides additional evidence of a pervasive abnormality of Purkinje cell biology in this disease, which affects multiple neuronal cellular compartments including their axon, cell body, dendrites and spines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.