Evidence map›Paper›PMID 25366991›Full record

ArticleScientific reports2014

High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser.

Pu Wang, Teng Ma, Mikhail N Slipchenko, Shanshan Liang, Jie Hui, K Kirk Shung, Sukesh Roy, Michael Sturek, Qifa Zhou, Zhongping Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Review
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  16. Article
  17. Photoacoustic Tomography Opening New Paradigms in Biomedical Imaging.Advances in experimental medicine and biology · 2021
    Article
  18. Review
  19. Review
  20. Biomedical optics express · 2020
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pu WangWeldon School of Biomedical Engineering, Purdue University, West Lafayette, 47906, USA.
Teng MaDepartment of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, California 90089, USA.
Mikhail N Slipchenko1] Weldon School of Biomedical Engineering, Purdue University, West Lafayette, 47906, USA [2] Spectral Energy, LLC, Dayton, Ohio, 45431, USA.
Shanshan Liang1] Department of Biomedical Engineering, University of California, Irvine, California 92697, USA [2] Beckman Laser Institute, University of California, Irvine, California 92612, USA and Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, California 92697, USA.
Jie HuiPhysics Department, Purdue University, West Lafayette, 47906, USA.
K Kirk ShungDepartment of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, California 90089, USA.
Sukesh RoySpectral Energy, LLC, Dayton, Ohio, 45431, USA.
Michael SturekDepartment of Cellular &Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, 46202, USA.
Qifa ZhouDepartment of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, California 90089, USA.
Zhongping ChenDepartment of Biomedical Engineering, University of California, Irvine, California 92697, USA.
Ji-Xin ChengWeldon School of Biomedical Engineering, Purdue University, West Lafayette, 47906, USA.

Funding

A Resource on Medical Ultrasonic Transducer TechnologyP41EB002182 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHUNG, K KIRK · 2003 to 2016
$13.3M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY · 2012 to 2017
$7.0M
Phase resolved ARF optical coherence elastography for intravascular imagingR01HL125084 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ZHOU, QIFA · 2014 to 2023
$5.6M
Integrated multi-modality intravascular US/OCT imaging systemR01EB010090 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING · 2009 to 2012
$2.3M
Vibrational Photoacoustic Microscopy for Bond-selective Tissue AnalysisR21EB015901 · NIBIB · PURDUE UNIVERSITY · PI CHENG, JI-XIN · 2012 to 2013
$385k
NCRR NIH HHS P41-RR2182NHLBI NIH HHS R01 HL125084NHLBI NIH HHS R01-HL-125084NIBIB NIH HHS P41 EB002182NIBIB NIH HHS P41 EB015890NIBIB NIH HHS P41EB-015890NIBIB NIH HHS R01 EB010090NIBIB NIH HHS R01EB-10090NIBIB NIH HHS R21 EB015901NIBIB NIH HHS R21 EB15901
6 · The paper itself

Abstract

Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (~50 s per frame) due to the lack of a suitable laser source for high-speed excitation of molecular overtone vibrations. Here, we report an improvement in IVPA imaging speed by two orders of magnitude, to 1.0 s per frame, enabled by a custom-built, 2-kHz master oscillator power amplifier (MOPA)-pumped, barium nitrite [Ba(NO3)2] Raman laser. This advancement narrows the gap in translating the IVPA technology to the clinical setting.

Indexed as

AnimalsDiagnostic ImagingIliac ArteryLasersLipidsPhantoms, ImagingPhotoacoustic TechniquesPlaque, AtheroscleroticSwineSwine, MiniatureLipids

Identifiers

PMID25366991
PMCPMC4219167

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.