ReviewAnnals of biomedical engineering2015
The powerful functions of peptide-based bioactive matrices for regenerative medicine.
Review in Annals of biomedical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.
- Nanomaterials Modulating the Fate of Dental-Derived Mesenchymal Stem Cells Involved in Oral Tissue Reconstruction: A Systematic Review.International journal of nanomedicine · 2023Pooled it
- Biodistribution and Biodegradation of an Osteoinductive Supramolecular Polymer Implant in a Rat Spinal Fusion Model.Journal of functional biomaterials · 2026Article
- Identifying a Novel BCL2L1-Targeting Peptide from Porcine Placenta for Lymphoma Therapy.ACS omega · 2025Article
- Reciprocity in dynamics of supramolecular biosystems for the clustering of ligands and receptors.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dual functionality of MDM2 in PROTACs expands the horizons of targeted protein degradation.Biomarker research · 2025Review
- Lipid-Based Nanoparticles as Oral Drug Delivery Systems: Overcoming Poor Gastrointestinal Absorption and Enhancing Bioavailability of Peptide and Protein Therapeutics.Advanced pharmaceutical bulletin · 2024Review
- Editorial: Biomaterials used in tissue engineering for the restoration of ocular disorders.Frontiers in pharmacology · 2024Article
- Forging out-of-equilibrium supramolecular gels.Nature synthesis · 2024Article
- A supramolecular polymer-collagen microparticle slurry for bone regeneration with minimal growth factor.Biomaterials · 2023Article
- Extracellular matrix type 0: From ancient collagen lineage to a versatile product pipeline - JellaGel™.Materials today. Bio · 2023Article
- Polymeric Nanocomposite Hydrogel Scaffolds in Craniofacial Bone Regeneration: A Comprehensive Review.Biomolecules · 2023Review
- Cell Adhesion Motif-Functionalized Lipopeptides: Nanostructure and Selective Myoblast Cytocompatibility.Biomacromolecules · 2023Article
- Silk-Elastin-like Polymers for Acute Intraparenchymal Treatment of the Traumatically Injured Spinal Cord: A First Systematic Experimental Approach.Pharmaceutics · 2022Article
- Self-assembling peptides-based nano-cargos for targeted chemotherapy and immunotherapy of tumors: recent developments, challenges, and future perspectives.Drug delivery · 2022Review
- An Overview of the Supramolecular Systems for Gene and Drug Delivery in Tissue Regeneration.Pharmaceutics · 2022Review
- Multipotential Role of Growth Factor Mimetic Peptides for Osteochondral Tissue Engineering.International journal of molecular sciences · 2022Review
- Peptide-based nanomaterials: Self-assembly, properties and applications.Bioactive materials · 2022Review
- Self-assembled gel tubes, filaments and 3D-printing withChemical science · 2022Article
- An amelogenin-based peptide hydrogel promoted the odontogenic differentiation of human dental pulp cells.Regenerative biomaterials · 2022Article
- Application of dental stem cells in three-dimensional tissue regeneration.World journal of stem cells · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In an effort to develop bioactive matrices for regenerative medicine, peptides have been used widely to promote interactions with cells and elicit desired behaviors in vivo. This paper describes strategies that utilize peptide-based molecules as building blocks to create supramolecular nanostructures that emulate not only the architecture but also the chemistry of the extracellular matrix in mammalian biology. After initiating a desired regenerative response in vivo, the innate biodegradability of these systems allow for the natural biological processes to take over in order to promote formation of a new tissue without leaving a trace of the nonnatural components. These bioactive matrices can either bind or mimic growth factors or other protein ligands to elicit a cellular response, promote specific mechano-biological responses, and also guide the migration of cells with programmed directionality. In vivo applications discussed in this review using peptide-based matrices include the regeneration of axons after spinal cord injury, regeneration of bone, and the formation of blood vessels in ischemic muscle as a therapy in peripheral arterial disease and cardiovascular diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.