ArticleClinical oral investigations2015
Comparison of gene expression between mandibular and iliac bone-derived cells.
Article in Clinical oral investigations, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
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- Site-specific periosteal cells with distinct osteogenic and angiogenic characteristics.Clinical oral investigations · 2023Article
- Uncovering the unique characteristics of the mandible to improve clinical approaches to mandibular regeneration.Frontiers in physiology · 2023Review
- Bevacizumab and sunitinib mediate osteogenic and pro-inflammatory molecular changes in primary human alveolar osteoblasts in vitro.Odontology · 2022Article
- Transcriptional Regulation of Jaw Osteoblasts: Development to Pathology.Journal of dental research · 2022Article
- A matter of origin - identification of SEMA3A, BGLAP, SPP1 and PHEX as distinctive molecular features between bone site-specific human osteoblasts on transcription level.Frontiers in bioengineering and biotechnology · 2022Article
- Efficacy of chitinase-3-like protein 1 as anRegenerative therapy · 2021Article
- Restriction of Dietary Phosphate Ameliorates Skeletal Abnormalities in a Mouse Model for Craniometaphyseal Dysplasia.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Osteogenic and angiogenic characterization of mandible and femur osteoblasts.Journal of molecular histology · 2019Article
- Differential osteopontin expression in human osteoblasts derived from iliac crest and alveolar bone and its role in early stages of angiogenesis.Journal of bone and mineral metabolism · 2019Article
- Effects of zoledronic acid and geranylgeraniol on the cellular behaviour and gene expression of primary human alveolar osteoblasts.Clinical oral investigations · 2016Article
- Bone regeneration capacities of alveolar bone mesenchymal stem cells sheet in rabbit calvarial bone defect.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study is to investigate the differences in gene expression between the human mandibular and iliac bone-derived cells (BCs) for better understanding of the site-specific characteristics of bones.
methodsPrimary cells were obtained from mandibular and iliac bones from six healthy, elderly donors. To investigate site-specific differences, gene expression profile of mandibular and iliac BC from the same donors were compared via cDNA microarray analysis.
resultsA comparison of the gene expression profiles revealed that 82 genes were significantly upregulated and 66 genes were downregulated with 1.5 fold or greater in mandibular versus iliac BCs. The most significantly differentially regulated genes were associated with skeletal system development or morphogenesis (SIX1, MSX1, MSX2, HAND2, PRRX1, OSR2, HOX gene family, PITX2). Especially, upregulated genes in mandibular BC were related with tooth morphogenesis, originated from the ectomesenchyme. Microarray analysis revealed that Msx1 was 2.03-fold and Msx2 was 1.99-fold upregulated in mandibular versus iliac BCs (both p < 0.01). Furthermore, in mandibular BCs, all members of the HOX gene family that were analyzed were downregulated (p < 0.01) and osteopontin was also downregulated by 2.84-fold (p < 0.01).
conclusionsSite-specific differences between jaw and long bones can be explained by the differences in gene expression patterns. Our results suggest that bone cell-derived cells maintain the genetic characteristics of their embryological origin. CLINICAL RELEVANCE: This study revealed fundamental differences in gene expression between the mandibular and iliac bone in humans. These differences could be important for understanding jaw bone-specific development of bisphosphonate-related osteonecrosis of the jaw.
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