ArticleAnnals of surgical oncology2015
Postoperative Nomogram for Predicting Cancer-Specific Mortality in Medullary Thyroid Cancer.
Article in Annals of surgical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Does the extent of neck surgery based on preoperative calcitonin level influence survival in medullary thyroid carcinoma: a retrospective tertiary centre experience.Annals of the Royal College of Surgeons of England · 2025Article
- Survival in medullary thyroid carcinoma patients who fail to achieve a biochemical cure: implications of postoperative 1-month calcitonin levels and targeted therapy.World journal of surgical oncology · 2024Article
- Sex differences and racial/ethnic disparities in the presentation and treatment of medullary thyroid cancer.American journal of surgery · 2024Article
- Well-defined survival outcome disparity across age cutoffs at 45 and 60 for medullary thyroid carcinoma: a long-term retrospective cohort study of 3601 patients.Frontiers in endocrinology · 2024Article
- Management of Medullary Thyroid Cancer: Patterns of Recurrence and Outcomes of Reoperative Surgery.The oncologist · 2023Article
- A proposed grading scheme for predicting recurrence in medullary thyroid cancer based on the Ki67 index and metastatic lymph node ratio.Endocrine · 2023Article
- Operative Management of Thyroid Disease in Older Adults.Journal of the Endocrine Society · 2023Review
- Diagnostic, Prognostic, and Predictive Role of Ki67 Proliferative Index in Neuroendocrine and Endocrine Neoplasms: Past, Present, and Future.Endocrine pathology · 2023Review
- Article
- Tumor Grade Predicts for Calcitonin Doubling Times and Disease-Specific Outcomes After Resection of Medullary Thyroid Carcinoma.Thyroid : official journal of the American Thyroid Association · 2022Article
- Construction and Validation of a Prediction Model for Identifying Clinical Risk Factors of Lateral Lymph Node Metastasis in Medullary Thyroid Carcinoma.International journal of general medicine · 2022Article
- A prediction model for the 5-year, 10-year and 20-year mortality of medullary thyroid carcinoma patients based on lymph node ratio and other predictors.Frontiers in surgery · 2022Article
- Lobectomy may be more appropriate for patients with early-stage medullary thyroid cancer older than 60 years old.Frontiers in endocrinology · 2022Article
- International Medullary Thyroid Carcinoma Grading System: A Validated Grading System for Medullary Thyroid Carcinoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Article
- Development and validation of pretreatment nomogram for disease-specific mortality in gastric cancer-A competing risk analysis.Cancer medicine · 2021Article
- Predicting Outcomes in Sporadic and Hereditary Medullary Thyroid Carcinoma over Two Decades.Thyroid : official journal of the American Thyroid Association · 2021Article
- Association between age and disease specific mortality in medullary thyroid cancer.American journal of surgery · 2021Article
- Medullary Thyroid Cancer in Patients Older than 45-Epidemiologic Trends and Predictors of Survival.Cancers · 2020Article
- Grading of medullary thyroid carcinoma on the basis of tumor necrosis and high mitotic rate is an independent predictor of poor outcome.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- A Nomogram for Predicting Cancer-Specific Survival of Patients with Gastrointestinal Stromal Tumors.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundMedullary thyroid cancer (MTC) is a rare thyroid cancer accounting for 5 % of all thyroid malignancies. The purpose of our study was to design a predictive nomogram for cancer-specific mortality (CSM) utilizing clinical, pathological, and biochemical variables in patients with MTC.
methodsMTC patients managed entirely at Memorial Sloan-Kettering Cancer Center between 1986 and 2010 were identified. Patient, tumor, and treatment characteristics were recorded, and variables predictive of CSM were identified by univariable analyses. A multivariable competing risk model was then built to predict the 10-year cancer specific mortality of MTC. All predictors of interest were added in the starting full model before selection, including age, gender, pre- and postoperative serum calcitonin, pre- and postoperative CEA, RET mutation status, perivascular invasion, margin status, pathologic T status, pathologic N status, and M status. Stepdown method was used in model selection to choose predictive variables.
resultsOf 249 MTC patients, 22.5 % (56/249) died from MTC, whereas 6.4 % (16/249) died secondary to other causes. Mean follow-up period was 87 ± 67 months. The seven variables with the highest predictive accuracy for cancer specific mortality included age, gender, postoperative calcitonin, perivascular invasion, pathologic T status, pathologic N status, and M status. These variables were used to create the final nomogram. Discrimination from the final nomogram was measured at 0.77 with appropriate calibration.
conclusionsWe describe the first nomogram that estimates cause-specific mortality in individual patients with MTC. This predictive nomogram will facilitate patient counseling in terms of prognosis and subsequent clinical follow up.
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