ArticleHuman brain mapping2015
Close-range blast exposure is associated with altered functional connectivity in Veterans independent of concussion symptoms at time of exposure.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines.Brain imaging and behavior · 2021Pooled it
- Characteristics and Impact of U.S. Military Blast-Related Mild Traumatic Brain Injury: A Systematic Review.Frontiers in neurology · 2020Pooled it
- In silico investigation of brain tissue responses associated with mild blast traumatic brain injury.Frontiers in bioengineering and biotechnology · 2026Article
- Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury.Brain communications · 2025Review
- Blast exposure and long-term diagnoses among veterans: a millennium cohort study investigation of high-level blast and low-level blast.Frontiers in neurology · 2025Article
- Metabolic syndrome is associated with reduced default mode network functional connectivity in young post-9/11 Veterans.Brain imaging and behavior · 2024Article
- Twenty Years of Blast-Induced Neurotrauma: Current State of Knowledge.Neurotrauma reports · 2024Article
- Effects of blast exposure on anxiety and symptoms of post-traumatic stress disorder (PTSD) among displaced Ukrainian populations.PLOS global public health · 2024Article
- EEG hyperexcitability and hyperconnectivity linked to GABAergic inhibitory interneuron loss following traumatic brain injury.Brain communications · 2024Article
- Blast-related mild TBI: LIMBIC-CENC focused review with implications commentary.NeuroRehabilitation · 2024Review
- Considerations for the assessment of blast exposure in service members and veterans.Frontiers in neurology · 2024Article
- Neuro-psychiatric symptoms in directly and indirectly blast exposed civilian survivors of urban missile attacks.BMC psychiatry · 2023Article
- Lifetime Blast Exposure Is Not Related to White Matter Integrity in Service Members and Veterans With and Without Uncomplicated Mild Traumatic Brain Injury.Neurotrauma reports · 2023Article
- Associations of mTBI and post-traumatic stress to amygdala structure and functional connectivity in military Service Members.Frontiers in neuroimaging · 2023Article
- Relationship between clinician documented blast exposure and pulmonary function: a retrospective chart review from a national specialty clinic.Respiratory research · 2022Article
- Plasma biomarkers associated with deployment trauma and its consequences in post-9/11 era veterans: initial findings from the TRACTS longitudinal cohort.Translational psychiatry · 2022Article
- Alterations in the Topology of Functional Connectomes Are Associated with Post-Traumatic Stress Disorder and Blast-Related Mild Traumatic Brain Injury in Combat Veterans.Journal of neurotrauma · 2021Article
- Blast mild traumatic brain injury is associated with increased myopia and chronic convergence insufficiency.Vision research · 2021Article
- Cerebral perfusion is associated with blast exposure in military personnel without moderate or severe TBI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
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Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Although there is emerging data on the effects of blast-related concussion (or mTBI) on cognition, the effects of blast exposure itself on the brain have only recently been explored. Toward this end, we examine functional connectivity to the posterior cingulate cortex, a primary region within the default mode network (DMN), in a cohort of 134 Iraq and Afghanistan Veterans characterized for a range of common military-associated comorbidities. Exposure to a blast at close range (<10 meters) was associated with decreased connectivity of bilateral primary somatosensory and motor cortices, and these changes were not different from those seen in participants with blast-related mTBI. These results remained significant when clinical factors such as sleep quality, chronic pain, or post traumatic stress disorder were included in the statistical model. In contrast, differences in functional connectivity based on concussion history and blast exposures at greater distances were not apparent. Despite the limitations of a study of this nature (e.g., assessments long removed from injury, self-reported blast history), these data demonstrate that blast exposure per se, which is prevalent among those who served in Iraq and Afghanistan, may be an important consideration in Veterans' health. It further offers a clinical guideline for determining which blasts (namely, those within 10 meters) are likely to lead to long-term health concerns and may be more accurate than using concussion symptoms alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.