ReviewSurgery today2015
Gastric adenocarcinoma with para-aortic lymph node metastasis: a borderline resectable cancer?
Review in Surgery today, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Is there a role for treatment-oriented surgery in stage IV gastric cancer? A systematic review.Updates in surgery · 2019Pooled it
- Surgery Matters: Progress in Surgical Management of Gastric Cancer.Current treatment options in oncology · 2023Review
- International Retrospective Cohort Study of Conversion Therapy for Stage IV Gastric Cancer 1 (CONVO-GC-1).Annals of gastroenterological surgery · 2022Article
- Favorable Outcomes of Neoadjuvant Chemotherapy and Limited Para-Aortic Lymph Node Dissection for Advanced Gastric Cancer with Para-aortic Lymph Node Metastasis.World journal of surgery · 2021Article
- Curative para-Aortic lymph node dissection Via INfra-mesocolonic approach in laparoscopic Gastrectomy (CAVING approach).Langenbeck's archives of surgery · 2021Article
- Trastuzumab-based palliative chemotherapy for HER2-positive gastric cancer: a single-center real-world data.BMC cancer · 2021Article
- The Clinicopathological Characteristics and Prognoses of dMMR Gastric Adenocarcinoma Patients.Gastroenterology research and practice · 2021Article
- Optimization of perioperative approaches for advanced and late stages of gastric cancer: clinical proposal based on literature evidence, personal experience, and ongoing trials and research.World journal of surgical oncology · 2020Review
- Significance of nodal dissection and nodal positivity in gastric cancer.Translational gastroenterology and hepatology · 2020Review
- Role of D2 gastrectomy in gastric cancer with clinical para-aortic lymph node metastasis.World journal of gastroenterology · 2019Article
- Recent Advances in the Surgical Treatment of Advanced Gastric Cancer: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2019Review
- Para-aortic lymphadenectomy in surgery for gastric cancer: current indications and future perspectives.Updates in surgery · 2018Review
- Clinical impact of molecular classifications in gastric cancer.Updates in surgery · 2018Review
- The long-term survival of stage IV gastric cancer patients with conversion therapy.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2018Article
- Is There Any Role for D3 Lymphadenectomy in Gastric Cancer?Frontiers in surgery · 2018Article
- Report of two Cases with Metastasis in Lymph NodesAlong the Posterior Leaf of the Bursa Omentalis at the Area of the Pancreatic Body, an Area not Routinely Examined in Standard Gastrectomy Plus Bursectomy for Advanced Gastric Cancer.Journal of gastrointestinal cancer · 2016Article
- Feasibility of neoadjuvant S-1 and oxaliplatin followed by surgery for resectable advanced gastric adenocarcinoma.Surgery today · 2016Article
- Is conversion therapy possible in stage IV gastric cancer: the proposal of new biological categories of classification.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Review
- Gastric cancer: Current status of lymph node dissection.World journal of gastroenterology · 2016Review
- Conversion therapy for stage IV gastric cancer-the present and future.Translational gastroenterology and hepatology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dissection of the para-aortic lymph nodes (PAN) had once been enthusiastically explored at dedicated centers throughout Japan. Reflecting the results of a randomized trial, however, the current standard surgery for advanced resectable gastric cancer does not include systematic dissection of the PAN. Gastric cancer with PAN metastases, currently considered distant metastases, is classified as Stage IV, and according to the algorithm of the Japanese guidelines, is not indicated for surgery with curative intent. Historical data indicates, however, that a certain proportion of long-term survivors can be introduced among patients with PAN metastasis through D2 + PAN dissection. The Japan Clinical Oncology Group launched a series of phase II trials exploring a strategy employing neoadjuvant chemotherapy followed by D2 + PAN dissection for patients radiologically diagnosed to harbor metastases to the PAN. The campaign was successful, with 57% of these patients surviving for 5 years after two cycles of neoadjuvant S-1/CDDP followed by surgery. This strategy is now the tentative standard, mentioned in the 4th version of the Japanese Gastric Cancer Treatment Guidelines as one of the current clinical questions, and could be replaced by a more powerful combination chemotherapy or treatment employing more or longer cycles of chemotherapy in the future. The relevance of the strategy consisting of neoadjuvant chemotherapy followed by D2 + PAN dissection and its fundamental difference from the concept of conversion therapy are discussed herein with reference to the literature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.