Evidence map›Paper›PMID 25366309›Full record

ReviewGenes, brain, and behavior2015

Integrated circuits and molecular components for stress and feeding: implications for eating disorders.

J A Hardaway, N A Crowley, C M Bulik, T L Kash

Abstract readReview
In one paragraph

Review in Genes, brain, and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Time to Address Eating Disorder Risk Among Medical Students.Behavioral sciences (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Divergent Roles of Nucleus Accumbens D1- and D2-MSNs in Regulating Hedonic Feeding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

J A HardawayBowles Alcohol Center, University of North Carolina at Chapel Hill, NC, USA.
N A Crowley
C M Bulik
T L Kash

Funding

UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash · 2003 to 2026
$46.3M
Probing Ethanol Induced Acceleration of Hindbrain and Amygdalar Pathology in an Alzheimer’s Disease ModelU01AA020911 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash, Zoe Anastasia McElligott · 2012 to 2026
$5.8M
The Role of Serotonin in Alcohol-Withdrawal Induced AnxietyR01AA019454 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash · 2010 to 2026
$5.6M
DREADD2.0: AN ENHANCED CHEMOGENETIC TOOLKITU01MH105892 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JIN, JIAN, KASH, THOMAS L. · 2014 to 2016
$3.0M
Postdoctoral Research Training in Eating DisordersT32MH076694 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2007 to 2016
$1.8M
NIAAA NIH HHS P60 AA011605NIAAA NIH HHS R01 AA019454NIAAA NIH HHS U01 AA020911NIMH NIH HHS T32 MH076694NIMH NIH HHS U01 MH105892
6 · The paper itself

Abstract

Eating disorders are complex brain disorders that afflict millions of individuals worldwide. The etiology of these diseases is not fully understood, but a growing body of literature suggests that stress and anxiety may play a critical role in their development. As our understanding of the genetic and environmental factors that contribute to disease in clinical populations like anorexia nervosa, bulimia nervosa and binge eating disorder continue to grow, neuroscientists are using animal models to understand the neurobiology of stress and feeding. We hypothesize that eating disorder clinical phenotypes may result from stress-induced maladaptive alterations in neural circuits that regulate feeding, and that these circuits can be neurochemically isolated using animal model of eating disorders.

Indexed as

Feeding BehaviorAnimalsBrainFeeding and Eating DisordersHumansStress, PsychologicalAnimal modelsanorexia nervosaanxietybinge eating disorderbulimia nervosaeating disordersfeedingneural circuitsplasticitystress

Identifiers

PMID25366309
PMCPMC4465370

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.