ReviewEuropean journal of applied physiology2015
Effects of physical activity upon the liver.
Review in European journal of applied physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Physical exercise for people with cirrhosis.The Cochrane database of systematic reviews · 2018Pooled it
- Physical Activity and the Biliary Tract in Health and Disease.Sports medicine (Auckland, N.Z.) · 2015Pooled it
- Inflammatory cytokines in general and central obesity and modulating effects of physical activity.PloS one · 2015Trial
- Inflammation-Insulin Resistance Crosstalk and the Central Role of Myokines.International journal of molecular sciences · 2025Review
- Pathomorphological Changes in the Liver and Expression of the tgfb1 Gene during Physical Activity and after Meldonium Administration in an Experiment in Rats.Bulletin of experimental biology and medicine · 2025Article
- Quantification of nutrient fluxes during acute exercise in mice.Cell metabolism · 2024Article
- Relationship between macronutrients and energy intake and liver serum transaminase levels in elderly athletes and non-athletes: findings from the Neyshabur longitudinal study on aging.BMC geriatrics · 2024Article
- Home-based circuit training improves blood lipid profile, liver function, musculoskeletal fitness, and health-related quality of life in overweight/obese older adult patients with knee osteoarthritis and type 2 diabetes: a randomized controlled trial during the COVID-19 pandemic.BMC sports science, medicine & rehabilitation · 2024Article
- Patients with Nonalcoholic Steatohepatitis and Advanced Liver Disease Have the Lowest Cardiorespiratory Fitness.Digestive diseases and sciences · 2023Article
- Physiological changes in captive elephants in Northern Thailand as a result of the COVID-19 tourism ban - muscle, liver, metabolic function, and body condition.Frontiers in veterinary science · 2023Article
- State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.Comprehensive Physiology · 2022Article
- Is the Activity-Based Anorexia Model a Reliable Method of Presenting Peripheral Clinical Features of Anorexia Nervosa?Nutrients · 2021Article
- Physical activity and liver health among urban and rural Chinese adults: results from two independent surveys.Journal of exercise science and fitness · 2021Article
- Issues on Trainability.Frontiers in physiology · 2021Review
- In Vitro and In Vivo Effects of Fermented Oyster-Derived Lactate on Exercise Endurance Indicators in Mice.International journal of environmental research and public health · 2020Article
- Walking in the Light: How History of Physical Activity, Sunlight, and Vitamin D Account for Body Fat-A UK Biobank Study.Obesity (Silver Spring, Md.) · 2020Article
- Muscle-Liver Substrate Fluxes in Exercising Humans and Potential Effects on Hepatic Metabolism.The Journal of clinical endocrinology and metabolism · 2020Article
- Article
- Engineered skeletal muscles for disease modeling and drug discovery.Biomaterials · 2019Review
- Associations of Aerobic Fitness and Maximal Muscular Strength With Metabolites in Young Men.JAMA network open · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo review the responses of the liver to acute and chronic physical activity and to summarize relationships between physical activity and liver health.
methodsA systematic search of HealthStar/Ovid from 1975 through June of 2013, supplemented by articles from other sources.
results351 of 8,010 articles identified by HealthStar/Ovid were supplemented by 92 other papers; after focussing, the review was reduced to 435 citations. Prolonged acute exercise reduces hepatic blood flow, stimulating hepatic glycogenolysis, gluconeogenesis and synthesis of some proteins; however, lipid metabolism shows little change. Glutathione depletion suggests oxidative stress. Enzymes affecting carbohydrate metabolism are up-regulated, and lipogenic enzymes are down-regulated. The main triggers are humoral, but hepatic afferent nerves, cytokines, reactive oxygen species, and changes in hepatic blood flow may all play some role. Regular aerobic exercise training improves blood glucose control during exercise by increasing glycogen stores and up-regulating enzymes involved in gluconeogenesis and carbohydrate metabolism. Resistance to oxidant stress is generally increased by training. Lipogenic enzymes are down-regulated, and lipid metabolism is augmented. Modulations of insulin, insulin-like growth factor, glucagon and interleukin-6 may trigger the adaptive responses to training. Cross-sectional and longitudinal studies show that regular exercise can reduce hepatic fat, but the effect on circulating aminotransferases is unclear and the modality and dose of physical activity optimizing health benefits need clarification.
conclusionsRegular moderate physical activity enhances liver health. Adverse functional changes can develop if habitual activity is inadequate, and extremely prolonged competitive exercise may also be harmful, particularly under harsh environmental conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.