ReviewCurrent topics in membranes2014
Temperature sensitivity of two-pore (K2P) potassium channels.
Review in Current topics in membranes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 67 citations in OpenAlex.
- Article
- Metabotropic Glutamatergic Signaling Adaptively Controls Trans-thalamic Communication.bioRxiv : the preprint server for biology · 2026Article
- Temperature and pH-dependent potassium currents of muscles of the stomatogastric nervous system of the crab,iScience · 2026Article
- Temperature and pH-dependent Potassium Currents of Muscles of the Stomatogastric Nervous System of the Crab,bioRxiv : the preprint server for biology · 2025Article
- TREK- 1 Ameliorates Secondary Brain Injury by Regulating Inflammatory Microenvironment via CX3 CL1-CX3 CR1 Pathway After Intracerebral Hemorrhage.Molecular neurobiology · 2025Article
- Analysis and management of thermal loads generated in vivo by miniaturized optoelectronic implantable devices.Device · 2025Article
- The Effects of Overexpressing K2p Channels in Various Tissues on Physiology and Behaviors.Insects · 2025Article
- Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females.Molecular metabolism · 2025Article
- Thermosensory Roles of G Protein-Coupled Receptors and Other Cellular Factors in Animals.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Microfabrication Technologies for Nanoinvasive and High-Resolution Magnetic Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Mechanosensitive ion channels in glaucoma pathophysiology.Vision research · 2024Review
- Article
- Focal brain cooling suppresses spreading depolarization and reduces endothelial nitric oxide synthase expression in rats.IBRO neuroscience reports · 2024Article
- Ion Channel Dysregulation Following Intracerebral Hemorrhage.Neuroscience bulletin · 2024Review
- Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer.International journal of molecular sciences · 2023Review
- Serum potassium changes during hypothermia and rewarming: a case series and hypothesis on the mechanism.Clinical kidney journal · 2023Article
- Emerging roles of mechanosensitive ion channels in acute lung injury/acute respiratory distress syndrome.Respiratory research · 2022Review
- Review
- A review of the bioeffects of low-intensity focused ultrasound and the benefits of a cellular approach.Frontiers in physiology · 2022Review
- Single infrared light pulses induce excitatory and inhibitory neuromodulation.Biomedical optics express · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Heat dramatically potentiates K2P channel activity and further affects excitation. This review focuses on the current understanding of the physiological role of heat-activated K2P current, and discusses the molecular mechanism of temperature gating in TREK-1, TREK-2, and TRAAK.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.