ArticleMycorrhiza2015
Arbuscular mycorrhiza increase artemisinin accumulation in Artemisia annua by higher expression of key biosynthesis genes via enhanced jasmonic acid levels.
Article in Mycorrhiza, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 106 citations in OpenAlex.
- Arbuscular mycorrhizal fungi enhance rose resistance to Lymantria dispar through JA-associated regulation of flavonoid biosynthesis.Mycorrhiza · 2026Article
- Mechanism allowing biochar to aid in arbuscular mycorrhizal colonization in Panax quinquefolius L. roots and improve secondary metabolite production.Mycorrhiza · 2025Article
- Paraglomus and Glomus arbuscular mycorrhizal fungi induce the green tea catechin quality index and phosphorus bioavailability in tropical soils.Mycorrhiza · 2025Article
- Widely Targeted Metabolomic Analysis Reveals the Improvement inMolecules (Basel, Switzerland) · 2024Article
- Advanced metabolic engineering strategies for increasing artemisinin yield inHorticulture research · 2024Article
- Improvement ofFrontiers in plant science · 2024Article
- Seaweed extract and arbuscular mycorrhiza co-application affect the growth responses and essential oil composition of Foeniculum vulgare L.Scientific reports · 2023Article
- Addition of Arbuscular Mycorrhizal Fungi Enhances Terpene Synthase Expression inLife (Basel, Switzerland) · 2023Article
- Arbuscular mycorrhizal fungi enhance active ingredients of medicinal plants: a quantitative analysis.Frontiers in plant science · 2023Article
- Arbuscular mycorrhiza alters the nutritional requirements in Salvia miltiorrhiza and low nitrogen enhances the mycorrhizal efficiency.Scientific reports · 2022Article
- Significance of Arbuscular Mycorrhizal Fungi in Mitigating Abiotic Environmental Stress in Medicinal and Aromatic Plants: A Review.Foods (Basel, Switzerland) · 2022Review
- Arbuscular mycorrhizal fungi and production of secondary metabolites in medicinal plants.Mycorrhiza · 2022Review
- Impact of Phosphatic Nutrition on Growth Parameters and Artemisinin Production inLife (Basel, Switzerland) · 2022Article
- Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand.Frontiers in plant science · 2022Review
- Article
- Combined Analysis of Pharmaceutical Active Ingredients and Transcriptomes ofFrontiers in plant science · 2022Article
- Root Endophytic Fungi Regulate Changes in Sugar and Medicinal Compositions ofFrontiers in plant science · 2022Article
- Review
- Pre-inoculation with arbuscular mycorrhizal fungi affects essential oil quality and the reproduction of root lesion nematode in Cymbopogon citratus.Mycorrhiza · 2021Article
- Review
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is becoming increasingly evident that the formation of arbuscular mycorrhiza (AM) enhances secondary metabolite production in shoots. Despite mounting evidence, relatively little is known about the underlying mechanisms. This study suggests that increase in artemisinin concentration in Artemisia annua colonized by Rhizophagus intraradices is due to altered trichome density as well as transcriptional patterns that are mediated via enhanced jasmonic acid (JA) levels. Mycorrhizal (M) plants had higher JA levels in leaf tissue that may be due to induction of an allene oxidase synthase gene (AOS), encoding one of the key enzymes for JA production. Non-mycorrhizal (NM) plants were exogenously supplied with a range of methyl jasmonic acid concentrations. When leaves of NM and M plants with similar levels of endogenous JA were compared, these matched closely in terms of shoot trichome density, artemisinin concentration, and transcript profile of artemisinin biosynthesis genes. Mycorrhization increased artemisinin levels by increasing glandular trichome density and transcriptional activation of artemisinin biosynthesis genes. Transcriptional analysis of some rate-limiting enzymes of mevalonate and methyl erythritol phosphate (MEP) pathways revealed that AM increases isoprenoids by induction of the MEP pathway. A decline in artemisinin concentration in shoots of NM and M plants treated with ibuprofen (an inhibitor of JA biosynthesis) further confirmed the implication of JA in the mechanism of artemisinin production.
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