ArticleKorean journal of pathology2014
Preparation of compact agarose cell blocks from the residues of liquid-based cytology samples.
Article in Korean journal of pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Predictors of Response to Autologous Dendritic Cell Therapy in Glioblastoma Multiforme.Frontiers in immunology · 2018Trial
- Assessment of an innovative synthetic matrix for enhanced cell preservation: evaluating its clinical utility and impact on diagnostic precision in thyroid fine-needle aspiration cytology.BMC endocrine disorders · 2026Article
- Assessing Determinants of Response to PARP Inhibition in GermlineInternational journal of molecular sciences · 2025Article
- Establishing 3D organoid models from patient-derived conditionally reprogrammed cells to bridge preclinical and clinical insights in pancreatic cancer.Molecular cancer · 2025Article
- Immunocytochemistry on frozen-embedded cell block for the diagnosis of hematolymphoid cytology specimen: a straightforward alternative to the conventional cell block.Journal of hematopathology · 2024Article
- Enhancing diagnostic precision in thyroid nodule assessment: evaluating the efficacy of a novel cell preservation technique in fine-needle aspiration cytology.Frontiers in endocrinology · 2024Article
- Cerebral Organoid Arrays for Batch Phenotypic Analysis in Sections and Three Dimensions.International journal of molecular sciences · 2023Article
- Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy.Nature communications · 2021Article
- Pleiotropic Effects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2019Article
- Microarray Embedding/Sectioning for Parallel Analysis of 3D Cell Spheroids.Scientific reports · 2019Article
- Brain-Derived Neurotrophin and TrkB in Head and Neck Squamous Cell Carcinoma.International journal of molecular sciences · 2019Article
- Nerve Growth Factor (NGF)-Receptor Survival Axis in Head and Neck Squamous Cell Carcinoma.International journal of molecular sciences · 2018Article
- Photodynamic Effect of Methylene Blue and Low Level Laser Radiation in Head and Neck Squamous Cell Carcinoma Cell Lines.International journal of molecular sciences · 2018Article
- Cell and Tissue Display: An Alternative Multipurpose Tool for Microscopy.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
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7 authors.
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Abstract
backgroundInevitable loss of diagnostic material should be minimized during cell block preparation. We introduce a modified agarose cell block technique that enables the synthesis of compact cell blocks by using the entirety of a cell pellet without the loss of diagnostic material during cell block preparations. The feasibility of this technique is illustrated by high-throughput immunocytochemistry using high-density cell block microarray (CMA).
methodsThe cell pellets of Sure- Path residues were pre-embedded in ultra-low gelling temperature agarose gel and re-embedded in standard agarose gel. They were fixed, processed, and embedded in paraffin using the same method as tissue sample processing. The resulting agarose cell blocks were trimmed and represented on a CMA for high-throughput analysis using immunocytochemical staining.
resultsThe SurePath residues were effectively and entirely incorporated into compact agarose cell buttons and embedded in paraffin. Sections of the agarose cell blocks revealed cellularities that correlated well with corresponding SurePath smears and had immunocytochemical features that were sufficient for diagnosis of difficult cases.
conclusionsThis agarose-based compact cell block technique enables preparation of high-quality cell blocks by using up the residual SurePath samples without loss of diagnostic material during cell block preparation.
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