ArticleBrain and behavior2014
Genetic basis of delay discounting in frequent gamblers: examination of a priori candidates and exploration of a panel of dopamine-related loci.
Article in Brain and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Steep delay discounting and addictive behavior: a meta-analysis of continuous associations.Addiction (Abingdon, England) · 2017Pooled it
- Right inferior frontal cortex activity correlates with tolcapone responsivity in problem and pathological gamblers.NeuroImage. Clinical · 2017Trial
- The Genoeconomics of Impulsive Intertemporal Choice: A Critical Review.Journal of the experimental analysis of behavior · 2026Review
- Externalizing as a common genetic influence for a broad spectrum of substance use and behavioral conditions: A developmental perspective from the Avon Longitudinal Study of Parents and Children.Addiction (Abingdon, England) · 2025Article
- Associations Between Taq1A/C957T Polymorphic Variants and Autonomic Responsivity in a Slot Machine Task: Influence of Real-Life Gambling Exposure and Sex.Journal of gambling studies · 2025Article
- Similarities and Differences in Genetics.Advances in experimental medicine and biology · 2025Review
- Delay Discounting in Established and Proposed Behavioral Addictions: A Systematic Review and Meta-Analysis.Frontiers in behavioral neuroscience · 2021Review
- Cumulative Influence of Inflammatory Response Genetic Variation on Long-Term Neurobehavioral Outcomes after Pediatric Traumatic Brain Injury Relative to Orthopedic Injury: An Exploratory Polygenic Risk Score.Journal of neurotrauma · 2020Article
- Dopamine and Gambling Disorder: Prospects for Personalized Treatment.Current addiction reports · 2019Article
- Prediction and Understanding of Resilience in Albertan Families: Longitudinal Study of Disaster Responses (PURLS) - Protocol.Frontiers in psychiatry · 2019Article
- The Blurred Future of Adolescent Gamblers: Impulsivity, Time Horizon, and Emotional Distress.Frontiers in psychology · 2017Article
- Clinical-genetic model predicts incident impulse control disorders in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2016Article
- Attention-Deficit/Hyperactivity Disorder and Monetary Delay Discounting: A Meta-Analysis of Case-Control Studies.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- The Behavioral Economics and Neuroeconomics of Alcohol Use Disorders.Alcoholism, clinical and experimental research · 2016Review
- Testing the Relations Among Family Disorganization, Delay Discounting, and Adolescent Alcohol Use: A Genetically Informed Study.Alcoholism, clinical and experimental research · 2016Article
- Genetic influences on delay discounting in smokers: examination of a priori candidates and exploration of dopamine-related haplotypes.Psychopharmacology · 2015Article
- Using Behavior Economics to Understand Alcohol Use Disorders: A Concise Review and Identification of Research Priorities.Current addiction reports · 2015Article
- Impulsive delayed reward discounting as a genetically-influenced target for drug abuse prevention: a critical evaluation.Frontiers in psychology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionDelay discounting is a behavioral economic index of impulsivity that reflects preferences for small immediate rewards relative to larger delayed rewards. It has been consistently linked to pathological gambling and other forms of addictive behavior, and has been proposed to be a behavioral characteristic that may link genetic variation and risk of developing addictive disorders (i.e., an endophenotype). Studies to date have revealed significant associations with polymorphisms associated with dopamine neurotransmission. The current study examined associations between delay discounting and both previously linked variants and a novel panel of dopamine-related variants in a sample of frequent gamblers.
methodsParticipants were 175 weekly gamblers of European ancestry who completed the Monetary Choice Questionnaire to assess delay discounting preferences and provided a DNA via saliva.
resultsIn a priori tests, two loci previously associated with delayed reward discounting (rs1800497 and rs4680) were not replicated, however, the long form of DRD4 VNTR was significantly associated with lower discounting of delayed rewards. Exploratory analysis of the dopamine-related panel revealed 11 additional significant associations in genes associated with dopamine synthesis, breakdown, reuptake, and receptor function (DRD3, SLC6A3, DDC, DBH, and SLC18A2). An aggregate genetic risk score from the nominally significant loci accounted for 17% of the variance in discounting. Mediational analyses largely supported the presence of indirect effects between the associated loci, delay discounting, and pathological gambling severity.
conclusionsThese findings do not replicate previously reported associations but identify several novel candidates and provide preliminary support for a systems biology approach to understand the genetic basis of delay discounting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.