ArticleBrain and behavior2014
Genetic variation in GABRA2 moderates peer influence on externalizing behavior in adolescents.
Article in Brain and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Genetics of child aggression, a systematic review.Translational psychiatry · 2024Pooled it
- Delinquent Behavior: Systematic Review of Genetic and Environmental Risk Factors.Clinical child and family psychology review · 2019Pooled it
- Prenatal exposure to alcohol and its impact on reward processing and substance use in adulthood.Translational psychiatry · 2024Article
- Prospective DNA Methylation Analysis of the CpG GABRA2 Receptor Subunit in Alcohol Dependence during Detoxification.Medicina (Kaunas, Lithuania) · 2022Article
- Genetic interactions with stressful environments in depression and addiction.BJPsych advances · 2021Article
- The Role of Ion Channel-Related Genes in Autism Spectrum Disorder: A Study Using Next-Generation Sequencing.Frontiers in genetics · 2021Article
- Time-varying Effects of GABRG1 and Maladaptive Peer Behavior on Externalizing Behavior from Childhood to Adulthood: Testing Gene × Environment × Development Effects.Journal of youth and adolescence · 2020Article
- The Adolescent Brain Cognitive Development (ABCD) study: Imaging acquisition across 21 sites.Developmental cognitive neuroscience · 2018Review
- Genetic influences on conduct disorder.Neuroscience and biobehavioral reviews · 2018Review
- Article
- Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2.Journal of abnormal psychology · 2015Article
- "Weeding out" violence? Translational perspectives on the neuropsychobiological links between cannabis and aggression.Aggression and violent behaviorArticle
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5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGenetic predisposition and environmental influences are both important factors in the development of problematic behavior leading to substance use in adolescence. Involvement with delinquent peers also strongly predicts adolescent externalizing behavior. Several lines of evidence support a role of GABRA2 on externalizing behavior related to disinhibition. However, whether this genetic association is influenced by the environment such as peer behavior remains unknown.
methodsWe examined the moderating role of GABRA2 genetic variation on the socialization model of delinquent peer affiliation (at ages 12-14 years) on externalizing behavior (at ages 15-17 years) in the Michigan Longitudinal Study (MLS) adolescent sample. The sample consisted of 244 adolescents (75 females and 152 with at least one parent with a DSM-IV lifetime alcohol dependence/abuse diagnosis). Peer delinquent activity reported by the participant and teacher-reported adolescent externalizing behavior (Teacher Report Form (TRF) were assessed.
resultsNo main effect of the GABRA2 SNP rs279826, which tags a large haplotype, on externalizing behavior was observed. However, there was a statistically reliable GABRA2 × peer delinquency interaction. The effect of peer delinquent involvement on externalizing scores and the rule breaking subscale is significantly stronger for those with the GG genotype compared to A-carriers, whereas there was no effect of genotype on externalizing in the absence of peer delinquent involvement. No interaction was observed for the aggression subscale.
conclusionOur results suggest that the genetic effect of GABRA2 on externalizing behavior, more specifically on rule breaking is, at least in part, due to its effect on susceptibility to environmental exposure (i.e., peer delinquency).
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