ReviewPsychological bulletin2015
Interoceptive dysfunction: toward an integrated framework for understanding somatic and affective disturbance in depression.
Review in Psychological bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
136 citing papers in PubMed, 4 syntheses or guidelines pooled it, 292 citations in OpenAlex.
- Effects of acupuncture on brain function in patients with depression: A meta-analysis of functional magnetic resonance imaging studies.Medicine · 2026Pooled it
- Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Pooled it
- Neural correlates of heart-focused interoception: a functional magnetic resonance imaging meta-analysis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Pooled it
- The Immediate and sustained benefits of two-week high-frequency aerobic exercise on depressive symptoms and frontal function in subthreshold depression: A randomized controlled trial.Translational psychiatry · 2026Trial
- Losing trust in body sensations: Interoceptive awareness and depression symptom severity among primary care patients.Journal of affective disorders · 2021Trial
- Functional neuroanatomy of interoceptive processing in children and adolescents: a pilot study.Scientific reports · 2019Trial
- Gamma-Hydroxybutyrate Increases Resting-State Limbic Perfusion and Body and Emotion Awareness in Humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Embodied pathways of recovery: interoceptive change and the reduction of depressive symptoms following Tai Chi in women aged 40-55 years.Archives of women's mental health · 2026Article
- A lesion-derived brain network of somatic symptoms for transdiagnostic individual application.BMC medicine · 2026Article
- Somatic Symptoms Before Menarche: The Role of Parents and Pain Sensitivity.The Journal of early adolescence · 2026Article
- The cognitive and motor determinants of the perception of effort.Cognitive, affective & behavioral neuroscience · 2026Article
- From Breath to Behavior: Respiratory Features Predict Visual Detection Performance.bioRxiv : the preprint server for biology · 2026Article
- Structural network alterations in adolescent major depression and bipolar disorder: a graph-theoretical and fixel-based analysis.BMC psychiatry · 2026Article
- Physical activity intensities and depression in colorectal cancer: interoceptive accuracy as a mediator and mindfulness as a moderator.Journal of cancer survivorship : research and practice · 2026Article
- Interoception in obsessive-compulsive and major depressive disorders.Frontiers in psychology · 2026Article
- Review
- Types and Diagnosis of Childhood Intellectual Disabilities: Advancing Accuracy for Better Outcomes.Children (Basel, Switzerland) · 2025Review
- Regulation of addiction by the insular cortex: The interplay between interoception and cognitive function.iScience · 2025Review
- Maltreatment effects on cognitive control functional connectivity across adolescence: Prospective links to young adult mental health.Development and psychopathology · 2025Article
76 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Depression is characterized by disturbed sleep and eating, a variety of other nonspecific somatic symptoms, and significant somatic comorbidities. Why there is such close association between cognitive and somatic dysfunction in depression is nonetheless poorly understood. An explosion of research in the area of interoception-the perception and interpretation of bodily signals-over the last decade nonetheless holds promise for illuminating what have until now been obscure links between the social, cognitive-affective, and somatic features of depression. This article reviews rapidly accumulating evidence that both somatic signaling and interoception are frequently altered in depression. This includes comparative studies showing vagus-mediated effects on depression-like behaviors in rodent models as well as studies in humans indicating both dysfunction in the neural substrates for interoception (e.g., vagus, insula, anterior cingulate cortex) and reduced sensitivity to bodily stimuli in depression. An integrative framework for organizing and interpreting this evidence is put forward which incorporates (a) multiple potential pathways to interoceptive dysfunction; (b) interaction with individual, gender, and cultural differences in interoception; and (c) a developmental psychobiological systems perspective, emphasizing likely differential susceptibility to somatic and interoceptive dysfunction across the lifespan. Combined with current theory and evidence, it is suggested that core symptoms of depression (e.g., anhedonia, social deficits) may be products of disturbed interoceptive-exteroceptive integration. More research is nonetheless needed to fully elucidate the relationship between mind, body, and social context in depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.