ArticlePloS one2014
Hypothalamic temperature of rats subjected to treadmill running in a cold environment.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Chronic supplementation of noni in diabetic type 1-STZ rats: effects on glycemic levels, kidney toxicity and exercise performance.Diabetology & metabolic syndrome · 2023Article
- Exercise-induced hypothalamic neuroplasticity: Implications for energy and glucose metabolism.Molecular metabolism · 2023Review
- Core body temperatures of rats subjected to treadmill exercise to fatigue or exhaustion: The journalTemperature (Austin, Tex.) · 2023Article
- Cold Exposure After Exercise Impedes the Neuroprotective Effects of Exercise on Thermoregulation and UCP4 Expression in an MPTP-Induced Parkinsonian Mouse Model.Frontiers in neuroscience · 2020Article
- Reduced Tolerance and Asymmetrical Crosstolerance to Effects of the Indole Quinuclidinone Analog PNR-4-20, a G Protein-Biased Cannabinoid 1 Receptor Agonist in Mice: Comparisons with ΔThe Journal of pharmacology and experimental therapeutics · 2019Article
- Article
- Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake.PLoS biology · 2018Article
- Tissue oxidative metabolism can increase the difference between local temperature and arterial blood temperature by up to 1.3Temperature (Austin, Tex.) · 2018Review
- Pre-exercise exposure to the treadmill setup changes the cardiovascular and thermoregulatory responses induced by subsequent treadmill running in rats.Temperature (Austin, Tex.) · 2018Article
- Short-term treadmill exercise in a cold environment does not induce adrenal Hsp72 and Hsp25 expression.The journal of physiological sciences : JPS · 2017Article
- Brain Temperature in Spontaneously Hypertensive Rats during Physical Exercise in Temperate and Warm Environments.PloS one · 2016Article
- Exercise activates compensatory thermoregulatory reaction in rats: a modeling study.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Can the Brain Benefits of Exercise Be Enhanced Without Additional Exercise?Journal of neurology & neuromedicineArticle
- Thermoregulatory responses in exercising rats: methodological aspects and relevance to human physiology.Temperature (Austin, Tex.)Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different strategies for cooling the body prior to or during physical exercise have been shown to improve prolonged performance. Because of ethical and methodological issues, no studies conducted in humans have evaluated the changes in brain temperature promoted by cooling strategies. Therefore, our first aim sought to measure the hypothalamic temperature (Thyp) of rats subjected to treadmill running in a cold environment. Moreover, evidence suggests that Thyp and abdominal temperature (Tabd) are regulated by different physiological mechanisms. Thus, this study also investigated the dynamics of exercise-induced changes in Thyp and Tabd at two ambient temperatures: 25°C (temperate environment) and 12°C (cold). Adult male Wistar rats were used in these experiments. The rats were implanted with a guide cannula in the hypothalamus and a temperature sensor in the abdominal cavity. After recovery from this surgery, the rats were familiarized with running on a treadmill and were then subjected to the two experimental trials: constant-speed running (20 m/min) at 12°C and 25°C. Both Thyp and Tabd increased during exercise at 25°C. In contrast, Thyp and Tabd remained unchanged during fatiguing exercise at 12°C. The temperature differential (i.e., Thyp - Tabd) increased during the initial min of running at 25°C and thereafter decreased toward pre-exercise values. Interestingly, external cooling prevented this early increase in the temperature differential from the 2nd to the 8th min of running. In addition, the time until volitional fatigue was higher during the constant exercise at 12°C compared with 25°C. Together, our results indicate that Thyp and Tabd are regulated by different mechanisms in running rats and that external cooling affected the relationship between both temperature indexes observed during exercise without environmental thermal stress. Our data also suggest that attenuated hypothalamic hyperthermia may contribute to improved performance in cold environments.
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