ArticlePloS one2014
Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza A disease severity.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Systemic cytokines drive conserved severity-associated myeloid responses across bacterial and viral infections.Communications biology · 2025Pooled it
- Natural killer cells against viral infection: from basic biology to immunotherapy.Precision clinical medicine · 2026Review
- Immune Responses to Influenza Infection in Children.Open forum infectious diseases · 2026Article
- Article
- Development and validation of a nomogram to predict severe influenza.Immunity, inflammation and disease · 2024Article
- Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans.Cell reports · 2024Article
- Article
- Establishment of a Risk Score Model for Early Prediction of Severe H1N1 Influenza.Frontiers in cellular and infection microbiology · 2021Article
- A blood RNA transcript signature for TB exposure in household contacts.BMC infectious diseases · 2020Article
- Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection.Cell reports · 2019Article
- What can we learn about influenza infection and vaccination from transcriptomics?Human vaccines & immunotherapeutics · 2019Review
- A curated transcriptome dataset collection to investigate the blood transcriptional response to viral respiratory tract infection and vaccination.F1000Research · 2019Article
- Sputum cell IL-1 receptor expression level is a marker of airway neutrophilia and airflow obstruction in asthmatic patients.The Journal of allergy and clinical immunology · 2018Article
- KLRD1-expressing natural killer cells predict influenza susceptibility.Genome medicine · 2018Article
- Host genes and influenza pathogenesis in humans: an emerging paradigm.Current opinion in virology · 2015Review
Corrections and comments
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Authors and funding
27 authors at 12 institutions in 6 countries.
Funding
Abstract
backgroundThe influenza A virus is an RNA virus that is responsible for seasonal epidemics worldwide with up to five million cases of severe illness and 500,000 deaths annually according to the World Health Organization estimates. The factors associated with severe diseases are not well defined, but more severe disease is more often seen among persons aged >65 years, infants, pregnant women, and individuals of any age with underlying health conditions. METHODOLOGY/PRINCIPAL
findingsUsing gene expression microarrays, the transcriptomic profiles of influenza-infected patients with severe (N = 11), moderate (N = 40) and mild (N = 83) symptoms were compared with the febrile patients of unknown etiology (N = 73). We found that influenza-infected patients, regardless of their clinical outcomes, had a stronger induction of antiviral and cytokine responses and a stronger attenuation of NK and T cell responses in comparison with those with unknown etiology. More importantly, we found that both interferon and ubiquitination signaling were strongly attenuated in patients with the most severe outcomes in comparison with those with moderate and mild outcomes, suggesting the protective roles of these pathways in disease pathogenesis. CONCLUSION/SIGNIFICANCES: The attenuation of interferon and ubiquitination pathways may associate with the clinical outcomes of influenza patients.
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Registered trials
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