ArticlePloS one2014
Deep sequencing identifies tissue-specific microRNAs and their target genes involving in the biosynthesis of tanshinones in Salvia miltiorrhiza.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- Mining the Candidate Transcription Factors Modulating Tanshinones' and Phenolic Acids' Biosynthesis Under Low Nitrogen Stress inInternational journal of molecular sciences · 2025Article
- Genome-Wide Identification and Functional Analysis ofInternational journal of molecular sciences · 2024Article
- The Smi-miR858a-Horticulture research · 2024Article
- Article
- SmMYB4 Is a R2R3-MYB Transcriptional Repressor Regulating the Biosynthesis of Phenolic Acids and Tanshinones inMetabolites · 2022Article
- MicroRNAs in Medicinal Plants.International journal of molecular sciences · 2022Review
- An insight into microRNA biogenesis and its regulatory role in plant secondary metabolism.Plant cell reports · 2022Review
- Effects of Different Processing Methods Based on Different Drying Conditions on the Active Ingredients ofMolecules (Basel, Switzerland) · 2022Article
- Isolation and Comprehensive in Silico Characterisation of a NewPlants (Basel, Switzerland) · 2022Article
- Chromosome-level genome assembly and resequencing of camphor tree (Horticulture research · 2022Article
- Biosynthesis of Secondary Metabolites Based on the Regulation of MicroRNAs.BioMed research international · 2022Review
- Transcriptional regulatory networks in response to drought stress and rewatering in maize (Zea mays L.).Molecular genetics and genomics : MGG · 2021Review
- Genome-wide identification and functional characterization of natural antisense transcripts in Salvia miltiorrhiza.Scientific reports · 2021Article
- Genome-Wide Identification of Circular RNAs Potentially Involved in the Biosynthesis of Secondary Metabolites inFrontiers in genetics · 2021Article
- smi-miR396b targeted SmGRFs, SmHDT1, and SmMYB37/4 synergistically regulates cell growth and active ingredient accumulation in Salvia miltiorrhiza hairy roots.Plant cell reports · 2020Article
- Tanshinone IIA Suppresses Glioma Cell Proliferation, Migration and Invasion Both in vitro and in vivo Partially Through miR-16-5p/Talin-1 (TLN1) Axis.Cancer management and research · 2020Article
- Analysis of the laccase gene family and miR397-/miR408-mediated posttranscriptional regulation inPeerJ · 2019Article
- Heterologous Expression ofInternational journal of molecular sciences · 2018Article
- Systematic analysis of DEMETER-like DNA glycosylase genes shows lineage-specific Smi-miR7972 involved in SmDML1 regulation in Salvia miltiorrhiza.Scientific reports · 2018Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salvia miltiorrhiza is one of the most popular traditional medicinal herbs in Asian nations. Its dried root contains a number of tanshinones, protocatechuic aldehyde, salvianolic acid B and rosmarinic, and is used for the treatment of various diseases. The finding of microRNAs (miRNAs) and their target genes will help understand their biological role on the biosynthesis of tanshinones in S. miltiorrhiza. In the present study, a total of 452 known miRNAs corresponding to 589 precursor miRNAs (pre-miRNAs), and 40 novel miRNAs corresponding to 24 pre-miRNAs were identified in different tissues of S. miltiorrhiza by high-throughput sequencing, respectively. Among them, 62 miRNAs express only in root, 95 miRNAs express only in stem, 19 miRNAs express only in leaf, and 71 miRNAs express only in flower, respectively. By the degradome analysis, 69 targets potentially cleaved by 25 miRNAs were identified. Among them, acetyl-CoA C-acetyltransferase was cleaved by miR5072, and involved in the biosynthesis of tanshinones. This study provided valuable information for understanding the tissue-specific expression patterns of miRNAs in S. miltiorrhiza, and offered a foundation for future studies of the miRNA-mediated biosynthesis of tanshinones.
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