ArticlePloS one2014
A quantile regression approach can reveal the effect of fruit and vegetable consumption on plasma homocysteine levels.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Dietary intakes of green leafy vegetables and incidence of cardiovascular diseases.Cardiovascular journal of AfricaPooled it
- Prevalence of Hyperhomocysteinaemia and Associated Factors among Ethiopian Adult Population in a 2015 National Survey.BioMed research international · 2020Trial
- Quantile regression based method for characterizing risk-specific behavioral patterns in relation to longitudinal left-censored biomarker data collected from heterogeneous populations.Journal of applied statistics · 2025Article
- Looking beyond the mean: quantile regression for comparative physiologists.The Journal of experimental biology · 2024Article
- The effect of cumulative exposure with unhealthy lifestyles on the H-type hypertension among Chinese adults: a community-based, propensity-score-matched, and case-control study.Frontiers in nutrition · 2024Article
- Frequent vegetable consumption is inversely associated with hypertension among indigenous Africans.European journal of preventive cardiology · 2022Article
- Green leafy vegetable intakes are inversely related to the incidence of stroke.European journal of preventive cardiology · 2022Article
- Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China.BMJ open · 2021Article
- Development of a short food frequency questionnaire to assess diet quality in UK adolescents using the National Diet and Nutrition Survey.Nutrition journal · 2021Article
- Dominant modifiable risk factors for stroke in Ghana and Nigeria (SIREN): a case-control study.The Lancet. Global health · 2018Article
- Article
- Impact of legumes and plant proteins consumption on cognitive performances in the elderly.Journal of translational medicine · 2017Article
- Fruit and vegetables consumption is associated with higher vitamin intake and blood vitamin status among European adolescents.European journal of clinical nutrition · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA reduction in homocysteine concentration due to the use of supplemental folic acid is well recognized, although evidence of the same effect for natural folate sources, such as fruits and vegetables (FV), is lacking. The traditional statistical analysis approaches do not provide further information. As an alternative, quantile regression allows for the exploration of the effects of covariates through percentiles of the conditional distribution of the dependent variable.
objectiveTo investigate how the associations of FV intake with plasma total homocysteine (tHcy) differ through percentiles in the distribution using quantile regression. MATERIALS AND
methodsA cross-sectional population-based survey was conducted among 499 residents of Sao Paulo City, Brazil. The participants provided food intake and fasting blood samples. Fruit and vegetable intake was predicted by adjusting for day-to-day variation using a proper measurement error model. We performed a quantile regression to verify the association between tHcy and the predicted FV intake. The predicted values of tHcy for each percentile model were calculated considering an increase of 200 g in the FV intake for each percentile.
resultsThe results showed that tHcy was inversely associated with FV intake when assessed by linear regression whereas, the association was different when using quantile regression. The relationship with FV consumption was inverse and significant for almost all percentiles of tHcy. The coefficients increased as the percentile of tHcy increased. A simulated increase of 200 g in the FV intake could decrease the tHcy levels in the overall percentiles, but the higher percentiles of tHcy benefited more.
conclusionsThis study confirms that the effect of FV intake on lowering the tHcy levels is dependent on the level of tHcy using an innovative statistical approach. From a public health point of view, encouraging people to increase FV intake would benefit people with high levels of tHcy.
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