ArticlePloS one2014
Measuring the chemical and cytotoxic variability of commercially available kava (Piper methysticum G. Forster).
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Evaluating the Pattern of Kava (Piper methysticum) Consumption in Australia by Wastewater-Based Epidemiology.Drug and alcohol review · 2026Article
- Kava (Piper methysticum) consumption patterns and conceptualizations: results from an online survey.Substance abuse treatment, prevention, and policy · 2026Article
- The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and insomnia: study protocol for a randomized clinical trial.BMC complementary medicine and therapies · 2024Article
- Flavokavains A- and B-Free Kava Enhances Resilience against the Adverse Health Effects of Tobacco Smoke in Mice.ACS pharmacology & translational science · 2024Article
- An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava.Journal of clinical medicine · 2022Review
- Anticancer activity of Momordica cochinchinensis (red gac) aril and the impact of varietal diversity.BMC complementary medicine and therapies · 2020Article
- Kava as a Clinical Nutrient: Promises and Challenges.Nutrients · 2020Review
- A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications.PloS one · 2018Article
- Kava-241 reduced periodontal destruction in a collagen antibody primed Porphyromonas gingivalis model of periodontitis.Journal of clinical periodontology · 2017Article
- Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes.Pharmaceutical biology · 2016Article
- Herbal Hepatotoxicity: Clinical Characteristics and Listing Compilation.International journal of molecular sciences · 2016Review
- Hepatotoxicity Induced by "the 3Ks": Kava, Kratom and Khat.International journal of molecular sciences · 2016Review
- The Honolulu Liver Disease Cluster at the Medical Center: Its Mysteries and Challenges.International journal of molecular sciences · 2016Review
- Flavokawains a and B in kava, not dihydromethysticin, potentiate acetaminophen-induced hepatotoxicity in C57BL/6 mice.Chemical research in toxicology · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Formerly used world-wide as a popular botanical medicine to reduce anxiety, reports of hepatotoxicity linked to consuming kava extracts in the late 1990s have resulted in global restrictions on kava use and have hindered kava-related research. Despite its presence on the United States Food and Drug Administration consumer advisory list for the past decade, export data from kava producing countries implies that US kava imports, which are not publicly reported, are both increasing and of a fairly high volume. We have measured the variability in extract chemical composition and cytotoxicity towards human lung adenocarcinoma A549 cancer cells of 25 commercially available kava products. Results reveal a high level of variation in chemical content and cytotoxicity of currently available kava products. As public interest and use of kava products continues to increase in the United States, efforts to characterize products and expedite research of this potentially useful botanical medicine are necessary.
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Registered trials
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