Evidence map›Paper›PMID 25365028›Full record

ArticlePloS one2014

Prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.

Fu-Chun Zhou, Wei-Min Hou, Chuan-Yue Wang, Gabor S Ungvari, Helen F K Chiu, Christoph U Correll, David H K Shum, David Man, Deng-Tang Liu, Yu-Tao Xiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 5 countries.

Fu-Chun ZhouBeijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Wei-Min HouBeijing Daxing Mental Health Center, Beijing, China.
Chuan-Yue WangBeijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Gabor S UngvariSchool of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia.
Helen F K ChiuDepartment of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China.
Christoph U CorrellDivision of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York, United States of America.
David H K ShumSchool of Psychology and Griffith Health Institute, Griffith University, Brisbane, Queensland, Australia.
David ManDepartment of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong SAR, China.
Deng-Tang LiuDepartment of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yu-Tao XiangFaculty of Health Sciences, University of Macau, Macao SAR, China.
Beijing Anding Hospital · CNCapital Medical University · CNChinese University of Hong Kong · CNGriffith University · AUHong Kong Polytechnic University · HKNorthwell Health · USShanghai Mental Health Center · CNUniversity of Macau · MOUniversity of Western Australia · AU

Funding

Role of microRNAs in HSC-mediated fibrogenesisR21AA022702 · NIAAA · CAROLINAS MEDICAL CENTER · PI SCHRUM, LAURA W · 2015 to 2016
$378k
NIAAA NIH HHS R21 AA022702
6 · The paper itself

Abstract

objectiveWe aimed at investigating prospective memory and its socio-demographic and neurocognitive correlates in non-psychotic, first-degree relatives (FDRs) of patients with schizophrenia compared to patients with first episode schizophrenia (FES), and healthy controls (HCs).

methodsForty-seven FES patients, 50 non-psychotic FDRs (23 offspring and 27 siblings) of patients with chronic schizophrenia (unrelated to the FES group) and 51 HCs were studied. The Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT) was used to measure time-based prospective memory (TBPM) and event-based prospective memory (EBPM) performance. Other cognitive functions (involving respective memory and executive functions) were evaluated with standardized tests.

resultsAfter controlling for basic demographic characteristics including age, gender and educational level, there was a significant difference between FDRs, FES and HCs with respect to both TBPM (F(2,142) = 10.4, p<0.001) and EBPM (F(2,142) = 10.8, p<0.001). Multiple linear regression analyses revealed that lower scores of the Hopkins Verbal Learning Test-Revised (HVLT-R) and the STROOP Word-Color Test (SWCT) contributed to TBPM impairment, while lower educational level and higher scores of the Color Trails Test-2 (CTT-2) contributed to EBPM deficit in FDRs.

conclusionsFDRs share similar but attenuated prospective memory impairments with schizophrenia patients, suggesting that prospective memory deficits may represent an endophenotype of schizophrenia.

Indexed as

Memory, EpisodicSchizophreniaAdultFemaleHumansMaleNeuropsychological TestsNuclear FamilyRisk FactorsYoung Adult

Identifiers

PMID25365028
PMCPMC4218767
OpenAlexW2026198904

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.