Evidence map›Paper›PMID 25364979›Full record

ArticleCellular reprogramming2014

Impaired neural differentiation potency by retinoic acid receptor-α pathway defect in induced pluripotent stem cells.

Pei-Shan Hou, Wen-Chin Huang, Wei Chiang, Wei-Che Lin, Chung-Liang Chien

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular reprogramming, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Pei-Shan Hou1 Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University , Taipei, 100, Taiwan .
Wen-Chin Huang
Wei Chiang
Wei-Che Lin
Chung-Liang Chien
National Taiwan University · TWInstitute of Cellular and Organismic Biology, Academia Sinica · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Induced pluripotent stem cells (iPSCs) are reprogrammed from somatic cells via ectopic gene expression and, similarly to embryonic stem cells (ESCs), possess powerful abilities to self-renew and differentiate into cells of various lineages. However, the neural differentiation potency of iPSCs remains unknown. In this study, we demonstrated the neural differentiation ability of iPSCs compared with ESCs using an retinoic acid (RA) induction system. The neural differentiation efficiency of iPSCs was obviously lower than that of ESCs. Retinoic acid receptor-α (RARα) was critical in the RA-induced neural differentiation of iPSCs, and the effect of RARα was confirmed by applying a specific RARα antagonist ER50891 to ESCs. These findings indicate that iPSCs do not possess the complete properties that ESCs have.

Indexed as

Cellular ReprogrammingAnimalsCell DifferentiationCells, CulturedEmbryonic Stem CellsInduced Pluripotent Stem CellsMiceNeuronsReceptors, Retinoic AcidRetinoic Acid Receptor alphaSignal TransductionTretinoinRara protein, mouseReceptors, Retinoic AcidRetinoic Acid Receptor alphaTretinoin

Identifiers

PMID25364979
PMCPMC4245853
OpenAlexW2313271146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.