ReviewFrontiers in cell and developmental biology2014
Epigenetics and type II diabetes mellitus: underlying mechanisms of prenatal predisposition.
Review in Frontiers in cell and developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Family history of diabetes and glycemic progression: A propensity score-based analysis using health checkup data.PloS one · 2026Article
- Epigenetic crossroads in metabolic and cardiovascular health: the role of DNA methylation in type 2 diabetes and cardiovascular diseases.Cardiovascular diabetology · 2025Review
- Early Life Stress (ELS) Effects on Fetal and Adult Bone Development.Children (Basel, Switzerland) · 2023Review
- Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease.BMC genomic data · 2021Article
- Altered Transcription Factor Binding and Gene Bivalency in Islets of Intrauterine Growth Retarded Rats.Cells · 2020Article
- Genome-wide DNA methylation profiling of human diabetic peripheral neuropathy in subjects with type 2 diabetes mellitus.Epigenetics · 2019Article
- Phenotype and biochemical heterogeneity in late onset Fabry disease defined by N215S mutation.PloS one · 2018Article
- Early-Life Nutritional Programming of Type 2 Diabetes: Experimental and Quasi-Experimental Evidence.Nutrients · 2017Review
- Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease.Frontiers in endocrinology · 2017Review
- Emerging Evidence of Epigenetic Modifications in Vascular Complication of Diabetes.Frontiers in endocrinology · 2017Review
- Epigenetic alterations induced by environmental stress associated with metabolic and neurodevelopmental disorders.Environmental epigenetics · 2016Review
- Perinatal exposure to germinated brown rice and its gamma amino-butyric acid-rich extract prevents high fat diet-induced insulin resistance in first generation rat offspring.Food & nutrition research · 2016Article
- Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy.Progress in retinal and eye research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type II diabetes mellitus (T2DM) is a widespread metabolic disorder characterized by insulin resistance precipitating abnormally high blood glucose levels. While the onset of T2DM is known to be the consequence of a multifactorial interplay with a strong genetic component, emerging research has demonstrated the additional role of a variety of epigenetic mechanisms in the development of this disorder. Heritable epigenetic modifications, such as DNA methylation and histone modifications, play a vital role in many important cellular processes, including pancreatic cellular differentiation and maintenance of normal β-cell function. Recent studies have found possible epigenetic mechanisms to explain observed risk factors, such as altered atherogenic lipid profiles, elevated body mass index (BMI), and impaired glucose tolerance (IGT), for later development of T2DM in children born to mothers experiencing both famine and hyperglycemic conditions. It is suggested that these epigenetic influences happen early during gestation and are less susceptible to the effects of postnatal environmental modification as was previously thought, highlighting the importance of early preventative measures in minimizing the global burden of T2DM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.